首页|基于基准关联度和模糊层次分析法-熵权法优化银翘马勃散的提取工艺

基于基准关联度和模糊层次分析法-熵权法优化银翘马勃散的提取工艺

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目的:为保证古今工艺质量一致,采用基准关联度和模糊层次分析法(fuzzy analytic hierarchy process,FAHP)-熵权法综合权重,结合Box-Behnken响应面实验设计优选银翘马勃散的提取工艺.方法:以银翘马勃散中绿原酸、异绿原酸A及异绿原酸C含量的合计量,连翘苷含量加上出膏率和指纹图谱相似度作为评价指标,采用Box-Behnken响应面实验对加水倍数、提取时间及提取次数进行考察,结合基准关联度和FAHP-熵权法计算综合得分,得到最佳提取工艺,并进行工艺验证.结果:优选出银翘马勃散最优提取工艺为:加8 倍处方量的水,提取3 次,每次1h.3 批工艺验证结果综合评分均值为87.91,RSD值为0.58%.结论:Box-Behnken响应面实验结合基准关联度和FAHP-熵权法优化银翘马勃散的提取工艺合理稳定,具有可行性.
Optimization of extraction process for Yinqiao Mabo Powder based on standard relation and fuzzy analytic hierarchy process combined with entropy weight method
Objective:To ensure the equivalence of the ancient and modern processes,a standard relation and the Fuzzy analytic hierarchy process(FAHP)-entropy weight method combined with Box-Behnken response surface test were used to optimize the extraction process of Yinqiao Mabo Powder.Methods:Taking the total amount of chlorogenic acid,isochlorogenic acid A and isochlorogenic acid C,the content of forsythia glycosides,the paste yield and the similarity of fingerprint profile as the evaluation indexes,the Box-Behnken response surface test was used to examine the water addition,extraction time and extraction frequency.Combining the baseline correlation and FAHP-entropy weighting method,a composite score was calculated to obtain the optimal extraction process and the process was validated.Results:The optimal extraction process was selected:adding 8-fold of water and extracting three times for 1 hour each time.The mean score of the three batches of process validation was 87.91 with an RSD of 0.58%.Conclusion:The optimization of the extraction process of Yinqiao Mabo Powder combined with Box-Behnken response surface testing by baseline correlation and FAHP-entropy weight method is reasonable,stable and feasible.

Yinqiao Mabo PowderBox-Behnken response surface methodstandard relationfuzzy analytic hierarchy processentropy weight methodextraction process

石羽文、刁元元、姜孟成、刘伟朋、李钠、贾艾玲

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长春中医药大学药学院,长春 130117

银翘马勃散 Box-Behnken响应面法 基准关联度 模糊层次分析法 熵权法 提取工艺

吉林省创新能力建设项目重大疫情防治经典名方制剂储备库建设项目

2021C002吉中医药发[2021]11号

2024

中国新药杂志
中国医药科技出版社 中国医药集团总公司 中国药学会

中国新药杂志

CSTPCD北大核心
影响因子：1.039
ISSN：1003-3734
年,卷(期)：2024.33(13)
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