Progress in oral soluble film for prevention and treatment of nausea and vomiting
Oral soluble film is a new type of mucosal drug delivery preparation that has received great attention in recent years.Because it can disintegrate in saliva quickly without chewing and additional water,the loaded active ingredients are directly absorbed by the oral mucosa,avoiding first-pass effect,improving the bioavailability of drugs and shortening the time of drug action.Its advantages provide a more suitable new choice for drug delivery for many diseases.Nausea and vomiting are common in clinical treatment.Problems of oral drugs such as constituting a new inducing factor for the original symptoms of such patients and increasing the psychological burden of patients can be prevented and solved by the unique preparation advantages of oral membrane.In this paper,80 articles related to the prevention and treatment of nausea and vomiting were selected.The development status of antiemetic oral membrane in clinical and research stages was reviewed from the aspects of accelerating drug release rate,improving bioavailability,and increasing patient compliance.The information of its clinical treatment advantages,prescription composition,preparation and characterization evaluation methods were summarized in order to provide technical support for the further development of oral soluble film preparations and the improvement of clinical efficacy in the treatment of nausea and vomiting.
oral soluble filmnausea and vomitingdominanceprescription compositionpreparation and characterization
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