Applications of new approach methodologies in new drug research and development
New drug research and development process has been affected adversely by extensive timelines and complexity,high expense,high risk and low success rate,which indicates that there is an urgent need to improve new drug research and development efficiency to get high quality drug candidates as fast as possible,which also is the dream of all new drug research and development companies.To overcome the shortages of traditional two-dimensional cell culture models and animal models including simplicity,less relevance to human,low predictability and/or high cost,developing and adopting new approach methodologies(NAMs)with high predictability and human relevance,reduced timeline and cost,and recognized animal welfare,are highly desirable.After advances in past few decades,the high-throughput omics,organoids,organ-on-chip,model-informed drug development,and artificial intelligence have become mature and demonstrated potential application value and perspective in new drug research and development.This review covers the applications of these NAMs in new drug research and development and intents to make the readers understand these NAMs and to promote the applications of these NAMs in new drug research and development.
new drug research and developmentnew approach methodologiesomicsorganoidsorgan-on-chipmodel-informed drug developmentartificial intelligence
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