Advances in drug delivery of small interfering RNA therapy for Alzheimer's disease
Alzheimer's disease is a neurodegenerative disease with insidious onset,and existing therapeutic drugs can only delay the progression of the disease and relieve symptoms.Small interfering RNAs have shown the potential to treat Alzheimer's disease by cutting mRNA encoding target genes,but stable delivery of siRNA to lesions requires overcoming many challenges.This review describes the pathological mechanisms of Alzheimer's disease,existing drug targets,advantages and challenges of siRNA therapy,research advances in delivery systems across the blood-brain barrier,novel siRNA delivery systems,and ongoing clinical trials of Alzheimer's drugs.We aim to provide reference for the research of siRNA therapy for Alzheimer's disease.
Alzheimer's diseasesmall interfering RNAblood-brain barrierdelivery system
NETL
NSTL
万方数据
