127例非小细胞肺癌免疫治疗不良反应分析
Analysis of adverse reactions in immunotherapy for 127 cases of non-small cell lung cancer
李凤 1梁燕 2边原 3方强 4周进 4周俊翔 4王怡鑫4
作者信息
- 1. 电子科技大学附属肿瘤医院/四川省肿瘤医院,成都 610041;电子科技大学医学院,成都 611731
- 2. 电子科技大学医学院,成都 611731
- 3. 电子科技大学附属四川省人民医院药学部,成都 610072
- 4. 电子科技大学附属肿瘤医院/四川省肿瘤医院,成都 610041
- 折叠
摘要
目的:分析127例非小细胞肺癌(non-small cell lung cancer,NSCLC)免疫治疗药物不良反应(adverse reaction,ADR)的发生特点及临床表现,为临床及时发现和控制用药安全风险提供依据.方法:提取医院2019年7月—2023年5月住院患者免疫治疗的127例NSCLC的ADR发生情况,并按照患者的性别和年龄、ADR累及的器官/系统及临床表现、引起ADR用药亚组等维度进行统计及复杂网络分析.结果:127例患者中,有114例患者发生ADR,其中男性患者91例,占比79.82％,60～74岁年龄组ADR患者最多,共50例(43.86％);ADR以消化系统、血液/淋巴系统的损害最为多见,恶心55例、呕吐53例、骨髓抑制48例.结论:60岁以上NSCLC患者在接受免疫治疗时发生ADR事件概率高,尤其是消化系统和血液/淋巴系统,由于血液/淋巴系统ADR对疾病疗效影响较大,临床应重点监测血液/淋巴系统ADR.
Abstract
Objective:To analyze the occurrence characteristics and clinical manifestations of adverse reactions(ADR)of immunotherapy in 127 cases of non-small cell lung cancer(NSCLC),and to provide evidence for timely detection and control on the risks of drug safety.Methods:127 patients with NSCLC treated with immunotherapy from July 2019 to May 2023 were analyzed by gender and age,ADR-involved organs/systems and clinical manifestations,and ADR subgroups.Results:Among 127 patients,114 patients had ADR,of which 91 were male,accounting for 79.82％.ADR patients aged 60 to 74 years were the most common,accounting for 50 cases(43.86％).The most common ADR was digestive system and blood/lymphatic system damages,and nausea in 55 cases,vomiting in 53 cases,myelosuppression in 48 cases.Conclusion:There is a high probability of ADR events in NSCLC patients over 60 years old receiving immunotherapy,especially in the digestive system and the blood/lymphatic system.Since ADR of the blood/lymphatic system has a great impact on the therapeutic effect of the disease,the adverse reactions of the blood/lymphatic system should be monitored clinically.
关键词
非小细胞肺癌/程序性死亡受体1/程序性死亡配体1/不良反应/分析评价/复杂网络/用药安全Key words
non-small cell lung cancer/programmed death-1/programmed death-ligand 1/adverse reactions/analysis and evaluation/complex network/drug safety引用本文复制引用
基金项目
四川省科技厅应用基础研究项目(2021YJ0118)
出版年
2024
NETL
NSTL
万方数据