Considerations on the clinical trial design of prophylactic drugs for respiratory viral infections
Respiratory viral infections cause great harm to public health.Common respiratory viruses include influenza virus,parainfluenza virus,respiratory syncytial virus,human metapheumovirus,rhinovirus,and novel coronavirus,etc.The essential key to controlling the spread is effective vaccination,to which are a beneficial supplement.This article reviews the development and clinical trials of the prophylactic drugs of the influenza virus,respiratory syncytial virus and novel coronavirus infection.The key points of prophylactic clinical trials involved in respiratory viral infections are also discussed,including study design,study population and efficacy endpoints,etc.,hoping to provide references for the drug research and development.
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