Research progress in 1-deoxynojirimycin derivatives with hypoglycemic activity
1-deoxynojirimycin is a polyhydroxypyridine alkaloid with various pharmacological activities.As a strong inhibitor of α-glucosidase,it has been widely studied in the field of hypoglycemia.In order to enhance its specificity and further increase its hypoglycemic activity,researchers mainly modify the structure of 1-deoxynojirimycin through principles of assembly,structural hybridization,and valence state enhancement.This article mainly summarized N-substituted 1-deoxynojirimycin derivatives with hypoglycemic activity in recent years,providing reference for their application in hypoglycemic therapy.
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