Research progress on drug-related autoimmune myositis
Autoimmune inflammatory myopathies(AIM)is a heterogeneous group of autoimmune diseases,often referred to idiopathic,frequently featuring involvement of skeletal muscle and extramuscular organs.The occurrence and development of part of autoimmune myositis are related to drugs:immune-mediated necrotizing myopathy is closely related to statins,and immune checkpoint inhibitors(ICIs)can induce ICI-myositis.Additionally,idiopathic inflammatory myopathy and ocular autoimmune myositis can also be related to COVID-19 vaccination under some circumstance.The disease will still progress even if the regarding medication is discontinued,and immunosuppressive therapy is required.This article aims to summarize the current research progress of myositis associated with statins,COVID-19 vaccine and ICIs from four aspects:epidemiology,pathogenesis,clinical features,treatment and prognosis,so as to improve clinical understanding and early diagnosis and treatment.
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