Research progress in novel oral phosphorus binders
The control of serum phosphorus using phosphate binders is an important tool in the treatment of patients with hyperphosphatemia.Traditional phosphate binder aluminum hydroxide has been phased out due to potential aluminum toxicity,and calcium-based phosphorus binders such as calcium carbonate may cause hypercalcemia,require relatively large dose of tablets,and poor patient compliance.Therefore,it is particularly important to study the novel oral phosphorus binders with high phosphorus binding ability,low toxic side effects and small daily tablet load.Based on the characteristics of non-aluminum and non-calcium phosphorus binders,the novel oral phosphorus binders were classified and discussed in this article,including preparation process,clinical safety and effectiveness.And the development trend of novel oral phosphorus binders was prospected.
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