Mirtazapine is the world's first antidepressant with dual inhibitory effects on norepinephrine and 5-hydroxytryptamine,and is developed by Oganon Company.In this paper,we conducted a search using the PatSnap patent search database,focusing on the analysis of mirtazapine in terms of patent application trends,patent layout of the original research companies,and the pulse of technological development.This paper found that the original research enterprise in the crystal form of mirtazapine patent layout is not tight enough,mirtazapine and other drugs in combination with the combination of compositions,preparations and uses is the hot spot of research and development in recent years.Domestic pharmaceutical companies can seize the opportunity of existed technical research gaps of mirtazapine to further research on crystal patents,and the patent layout of mirtazapine by the original research enterprise can provide certain references for domestic pharmaceutical companies.