Research progress in pain management and pharmacological treatment for lumbar facet joint osteoarthritis
Lumbar facet joint osteoarthritis(FJOA)is the cause of chronic low back pain and is prevalent in elderly.Tissue damage and inflammation resulting from degenerative lumbar facet joints can cause the release of inflammatory factors that stimulate teleneuron and cause pain.Drug therapy lays foundation of the pain management of FJOA,and should be maintained in the whole disease course.In general,the principles of step and individual pain care are recommended for the treatment of FJOA.Patients could choose the appropriate treatment plan according to the actual situation.Non-steroidal anti-inflammatory drugs(NSAIDs)are commonly used as first-line treatment drugs in clinical practice.Topical patches are recommended by multiple guidelines as the preferred drugs for patients with osteoarthritis due to their comparable efficacy and superior safety than oral preparations.Acetaminophen is only recommended for short-term treatment or adjuvant therapy while opioids should be used with caution in clinical use due to safety consideration as well as addiction risk.
NETL
NSTL
万方数据
