Optimization of the preparation process of Yuhuang Shengji Cream based on definitive screening design
Objective:With the help of definitive screening design,the key process parameters were systematically optimized for the preparation process of Yuhuang Shengji Cream.Methods:A series of experiments were designed according to the definitive screening design,and the rheological properties of the cream were tested with a rotary rheometer to obtain the key rheological data.The complex relationship between factors and responses was explored by stepwise regression analysis of experimental data,based on which the simulation experiment was carried out,and the decision tree was used to determine the most appropriate range of factors to improve the stability of the preparation process.The Gauss process optimization method was applied to find the optimal parameter configuration in the preset range to further optimize the preparation process of Yuhuang Shengji cream.Results:The optimal process range obtained by optimization is as follows:emulsification temperature at(85±5.5)℃,mixing speed at(432±51)×g,drug proportion of(20±2)%,stearyl alcohol(14.1±1)g,white vaseline(30±2)g,and sodium dodecyl sulfate(1±0.16)g.The fluctuation in a small range did not have a great impact on the cream.The optimal process was as follows:drug proportion of 20%,emulsification temperature at 85℃,mixing speed at 432×g,stearyl alcohol 14 g,white vaseline 30 g,and sodium dodecyl sulfate 1 g.Under this condition,the probability of defect in cream production is 0.04329.Conclusion:The preparation process of Yuhuang Shengji cream was effectively optimized using the definitive screening design method.This method provides a reference for the preparation process optimization of other traditional Chinese medicine compound creams.
clinical experience formulatraditional Chinese medicine compound containing mineral medicinecreampreparation processdefinitive screening designrheologymachine learning
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