Clinical comprehensive evaluation of triple viable bacteria microecological preparations in prevention and treatment of diarrhea
Objective:To conduct an evaluation of the clinical comprehensive value of triple viable bacteria microecological preparations,including Golden Bifid,Perficon,Bifid,JuKe,and ShiYi,in preventing and treating pediatric and adult diarrhea.Methods:In accordance with the"Guidelines for the Management of Comprehensive Clinical Evaluation of Drugs ( Trial Version 2021 )",the evaluation was carried out using methods of evidence-based medicine literature research,comparative studies,and cost-minimization analysis in six dimensions of safety,effectiveness,economy,innovativeness,suitability,and accessibility.Results:In terms of safety,the package inserts of the five medicines have different emphasis on the items related to safety.Particularly,Golden Bifid stands out for its safer strain composition due to absence of Enterococcus.In terms of effectiveness,it shows no significant differences among the evaluated medicines.In terms of economic performance,the treatment costs of Bifid,Perficon,and Golden Bifid are at the same level,whereas the treatment costs of JuKe and ShiYi are significantly higher.In terms of innovativeness,both Golden Bifid and Perficon are classified as class I biological products,which outrun the other three medicines.Moreover,Golden Bifid particularly includes indication of diarrhea unresponsive to antibiotic therapy.In terms of suitability,Golden Bifid and ShiYi perform better,especially regarding the suitability for pediatric use,both providing detailed descriptions for children's medication.Golden Bifid,in particular,offers clear dosage recommendations for pediatric patients of different age groups.In terms of accessibility,Golden Bifid and Perficon are slightly better than Bifid,JuKe,and ShiYi.Conclusion:The effectiveness of these five triple viable bacteria microecological preparations shows no significant difference.Regarding the remaining five dimensions,the prioritization of advantages of the five medicines varies.Therefore,reasonable selection of medicines for treatment should be based on the actual situation in clinical practice.
triple viable bacteria microecological preparationdiarrheaadultschildrencomprehensive clinical evaluation of drugs
万方数据
维普
