Correlation between obstructive sleep apnea hypopnea syndrome and ventricular arrhythmia
Objective To explore the relationship between obstructive sleep apnea hypopnea syndrome(OSAHS)and ventricular arrhythmia.Methods Patients with OSAHS admitted to Zhongshan Hospital,Fudan University(Xiamen Branch)from January 2021 to September 2023 were using the Lown system to classify the ventricular ar-rhythmia.All subjects completed the general data collection,polysomnography(PSG)and Holter.According to the apnea hypopnea index(AHI),the severity of OSAHS patients was divided into mild group,moderate group,and severe group.The general clinical characteristics and incidence of ventricular arrhythmias during the whole day,a-wake and sleep periods were compared among each group;Further grouping was conducted to determine whether Lown level Ⅲ or above during sleeping.One-way analysis of variance was used to compare the general clinical char-acteristics and PSG parameters among different groups.Binary logistic regression analysis was conducted to investi-gate the influencing factors of ventricular arrhythmias.Results A total of 199 patients was divided into mild group(n=63),moderate group(n=65)and severe group(n=71).The results showed that as the severity of OSAHS increased,the proportion of patients with body mass index(BMI)and Lown level Ⅲ or above during sleeping were increased(P＜0.05);Compared with patients with Lown level Ⅲ or below,patients with Lown level Ⅲ or above during sleeping have an increase in age,proportion of coro-nary heart disease and the percentage of cumulative time with oxygen saturation below 90％in total sleep time(T90),while average pulse oxygen saturation(SpO2)and lowest SpO2 were decreased(P＜0.05).The binary logistic regression analysis found that patients with Lown levelⅢ or above during sleeping increased in age[odds ratio(OR)=1.050,95％confidence interval(CI)=1.017-1.085]and decreased in minimum SpO2(OR=0.926,95％CI=0.865-0.991)compared to patients with Lown level Ⅲ or below(all P＜0.05).Conclusion The more severe the condition of OSAHS,the higher the proportion of patients with Lown level Ⅲ or above during sleeping.Age and the lowest SpO2 are independent related factors for OSAHS patients with sleep stage Low grade Ⅲ and above.[Chinese Journal of Cardiac Pacing and Electrophysiology,2024,38(2):105-108]
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