Objective To discuss the correlation between neutrophil/lymphocyte ratio(NLR)and left atrial thrombosis in patients with non-valvular atrial fibrillation(NVAF),and clinical value of NLR in predicting NVAF complicated by left atrial thrombosis.Methods The clinical materials were retrospectively analyzed in NVAF patients(n=387)received examination of transesophageal echocardiography(TEE)in People's Hospital of Henan Province from Jan.2012 to Jan.2018.According to TEE results,all patients were divided into thrombosis group(n=46)and non-thrombosis group(n=341).The general clinical materials and indexes of laboratory examination and echocardiogram were compared between 2 groups.The risk factors related to left atrial thrombosis were analyzed by using single-factor and multi-factor Logistic regressions in NVAF patients.The clinical value of NLR in predicting NVAF complicated by left atrial thrombosis was reviewed by using ROC curve and AUC analyses.Results The comparison in general clinical materials showed that age,AF course,percentage of non-paroxysmal atrial fibrillation(PAF),heart failure,stroke history and CHA2DS2-VASc score were all higher in thrombosis group than those in non-thrombosis group(P<0.05).The comparison in indexes of laboratory examination showed that levels of neutrophile granulocyte,NLR,C-reactive protein(CRP)and N-terminal pro-brain natriuretic peptide(NT-proBNP)were higher,and lymphocyte was lower in thrombosis group than those in non-thrombosis group(P<0.05).The comparison in indexes of echocardiogram showed that left atrial diameter(LAD)was higher,and left ventricular ejection fraction(LVEF)was lower in thrombosis group than those in non-thrombosis group(P<0.05).The multi-factor Logistic regression analysis showed that non-PAF,stroke history,high CHA2DS2-VASc score,increased NLR,CRP and LAD were independent risk factor(P<0.05),and LVEF was an independent protective factor(P<0.05)of NVAF complicated by left atrial thrombosis.The results of ROC curve analysis showed that AUC of NLR in predicting NVAF complicated by left atrial thrombosis was 0.733(95%CI:0.686～0.776,P<0.001),and AUC of NLR combined with CHA2DS2-VASc score was 0.771(95%CI:0.726～0.812,P<0.001).Conclusion The increased NLR is an independent risk factor of NVAF complicated by left atrial thrombosis.The predictive value of CHA2DS2-VASc combined with NLR was higher than that of only CHA2DS2-VASc score.
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