Objective To discuss the relationship among solute carrier organic anion transporter family 1B1(SLCO1B1),apolipoprotein E(ApoE)gene polymorphism and coronary heart disease(CHD).Methods CHD patients(n=80)were chosen into observation group,and controls(n=80)were chosen into control group from Department of Cardiovascular Medicine in Wuwei Tumor Hospital of Gansu Province from Jan.2020 to June 2022.SLCO1B1 and ApoE gene polymorphism were respectively detected after collected peripheral blood samples.The indexes of blood fat were detected by using automatic biochemical analyzer,and risk factors of CHD were analyzed by using Logistic analysis.Results The comparison in genotypes 15/15,1a/15,1a/1a,1a/1b,1a/5,1b/15 and 1b/1b and alleles 15,1a,1b and 5 of SLCO1B1 had no statistical significance between 2 groups(P>0.05).The proportion of alleles ε2 and ε3 of ApoE was significantly higher in observation group than that in control group(P<0.05).Compared with control group,the levels of TC,TG,LDL-C and apolipoprotein B(ApoB)increased in genotype 1b/15 of SLCO1B1,TG increased in genotype 1a/15,HDL-C and ApoA1 decreased in genotype 1a/1b,and TG increased and HDL-C and ApoA1 decreased in genotype 1b/1b in observation group(P<0.05).Compared with control group,HDL-C decreased in genotype E2/E3 of ApoE,TG increased and HDL-C and ApoA1 decreased in genotype E3/E3,and HDL-C and ApoA1 decreased in genotype E3/E4 in observation group(P<0.05).The results of Logistic regression analysis showed that hypertension,diabetes,TG,LDL-C,ApoA1,ApoB and genotype ε4 of ApoE were risk factors for inducing CHD(P<0.05).Conclusion SLCO1B1 and ApoE gene polymorphism are correlation to dyslipidemia,and genotype ε4 of ApoE can improve CHD occurrence.
关键词
冠心病/载脂蛋白E/溶质载体有机阴离子转运蛋白家族1B1
Key words
Coronary heart disease/Apolipoprotein E/Solute carrier organic anion transporter family 1B1
维普
万方数据