Correlation between rs10494366 of single nucleotide polymorphism in NOS1AP gene and ventricular arrhythmias events in patients with implantable cardioverter defibrillator for secondary prevention
Correlation between rs10494366 of single nucleotide polymorphism in NOS1AP gene and ventricular arrhythmias events in patients with implantable cardioverter defibrillator for secondary prevention
Objective To investigate the predictive value of genotype TT in rs10494366 site in NOS1AP gene to events of ventricular arrhythmias(VA)in patients with implantable cardioverter defibrillator(ICD)for secondary prevention.Methods The patients with ICD were chosen into case group(n=122)and heathy controls were chosen into control group(348)from the Second Area of Arrhythmias,People's Hospital,Zhengzhou University from Sept.2013 to June 2017.The correlation between genotype TT of rs10494366 site in NOS1AP gene and ICD was analyzed by using case-control study.All objects were followed up for a long time,and they were given a programmed examination on the 3rd month,12th month and 3rd year after ICD implantation.The correlation among VA events,appropriate treatment and 3 genotypes(genotypes GG,GT and TT)was analyzed.Meanwhile the influences of genotypes GG,GT and TT in rs10494366 site on mortality were reviewed.Results The genotype TT in rs10494366 site was positively correlated to prolonged QT interval(β=9.443,P=0.020).The results off case-control study showed that genotype TT in rs10494366 site was correlated to patients with ICD and appropriate treatment(P=0.014 in allele mode).After followed up for(31.70±9.15)months,there was difference in ICD discharge times(Z=7.628,P=0.022)in patients with 3 genotypes in rs10494366 site,and ICD discharge frequency and times were increased in patients with genotype TT.The results of Kaplan-Meier curve analysis showed that the survival prognosis was poorer in patients with genotype TT than that in patients with other 2 genotypes(P=0.005).The results of Cox regression analysis showed that genotype TT in rs10494366 site was a high-risk factor of sudden cardiac death(SCD),and mortality risk of genotype TT increased by 2.944 compared with genotype GG(P=0.014).Conclusion The genotype TT in rs10494366 site in NOS1AP gene increases discharge treatment events in patients with ICD for secondary prevention,which can be taken as a factor for risk prediction.Therefore,detecting the genotype in this site has some reference value in clinical practice.
维普
万方数据