中国循证心血管医学杂志2024，Vol.16Issue(1) ：96-99.DOI:10.3969/j.issn.1674-4055.2024.01.20

新活素联合多巴胺治疗毛细血管前肺动脉高压所致右心衰竭的疗效观察

Curative effect of recombinant human brain natriuretic peptide combined with dopamine on right heart failure induced by precapillary pulmonary arterial hypertension

郑禹樵 刘丽 马丽娜 陈金良 苏志新
中国循证心血管医学杂志2024，Vol.16Issue(1) ：96-99.DOI:10.3969/j.issn.1674-4055.2024.01.20
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新活素联合多巴胺治疗毛细血管前肺动脉高压所致右心衰竭的疗效观察

Curative effect of recombinant human brain natriuretic peptide combined with dopamine on right heart failure induced by precapillary pulmonary arterial hypertension

郑禹樵 1刘丽 1马丽娜 2陈金良 3苏志新3
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作者信息

  • 1. 066000 秦皇岛,秦皇岛市第一医院心内科
  • 2. 066000 秦皇岛,秦皇岛市第一医院神经内科
  • 3. 066000 秦皇岛,解放军北戴河康复疗养中心心内科
  • 折叠

摘要

目的 观察新活素联合多巴胺治疗毛细血管前肺动脉高压所致右心衰竭的临床疗效.方法 选取于2022年2月至2022年12月秦皇岛市第一医院收治的毛细血管前肺动脉高压所致右心衰竭患者104例.随机分为对照组(抗右心衰竭常规治疗)34例、A组(常规治疗+新活素持续静脉滴注)33例、B组(常规治疗+新活素持续静脉滴注+多巴胺静脉滴注)37例.比较各组治疗前后血脑钠肽(BNP)值、右心室面积变化分数(FAC)、三尖瓣环收缩期位移(TAPSE)、右心室心脏指数(RCI)、肺动脉平均压(PAMP)及治疗中低血压发生率.结果 三组基线数据对比无统计学差异.BNP值:治疗后三组均下降,A组、B组低于对照组(P＜0.05),B组低于A组(P＜0.05),三组间存在统计学差异(F=41.2,P＜0.01).FAC、TAPSE、RCI:治疗后三组均升高,A组、B组高于对照组(P＜0.05),B组高于A组(P＜0.05),三组间存在统计学差异(FFAC=41.6,FTAPSE=48.0,FRCI=183.1,P均＜0.01).PAMP:治疗后三组均下降,A组、B组低于对照组(P＜0.05),A组、B组间无统计学差异(P＞0.05),三组间存在统计学差异(F=5.0,P＜0.01).低血压发生率:对照组11.8%、A组24.2%,B组2.7%,三组间有统计学差异(P=0.023).结论 新活素联合多巴胺静脉滴注可有效改善毛细血管前肺动脉高压所致右心衰竭患者的右心功能,并降低治疗中低血压的发生率.

Abstract

Objective To observe the clinical efficacy of recombinant human brain natriuretic peptide(rhBNP)combined with dopamine on right heart failure induced by precapillary pulmonary arterial hypertension(PAH).Methods The patients with right heart failure induced by precapillary PAH(n=104)were chosen from the First Hospital of Qinhuangdao City from Feb.2022 to Dec.2022.All patients were randomly divided into control group(given routine treatment,n=34),group A(given routine treatment and continuous intravenous infusion of rhBNP,n=33)and group B(given routine treatment and continuous intravenous infusions of rhBNP and dopamine,n=37).The levels of BNP,fractional area change(FAC)of right ventricle,tricuspid annular plane systolic excursion(TAPSE),right ventricular cardiac index(RCI)and pulmonary arterial mean pressure(PAMP),and incidence of hypotension during treatment were compared among all groups.Results The comparison in baseline data had no statistical difference among 3 groups.BNP decreased in 3 groups after treatment,and it was lower in groups A and B than that in control group(P<0.05)and lower in group B than that in group A(P<0.05).There was statistical difference among 3 groups(F=41.2,P<0.01).FAC,TAPSE and RCI increased in 3 groups after treatment,and they were higher in groups A and B than those in control group(P<0.05),and higher in group B than that in group A(P<0.05).There was statistical difference among 3 groups(FFAC=41.6,FTAPSE=48.0,FRCI=183.1,all P<0.01).PAMP decreased in 3 groups after treatment,and was lower in groups A and B than that in control group(P<0.05)and there was no statistical difference between group A and group B(P>0.05).There was statistical difference among 3 groups(F=5.0,P<0.01).The incidence rate of hypotension was 11.8%in control group,24.2%in group A and 2.7%in group B(P=0.023).Conclusion RhBNP combined with dopamine can effectively improve right heart function in patients with right heart failure induced by precapillary PAH and reduce the incidence of hypotension.

关键词

右心衰竭/低血压/新活素/多巴胺

Key words

Right heart failure/Hypotension/Recombinant human brain natriuretic peptide/Dopamine

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出版年

2024
中国循证心血管医学杂志
中国人民解放军北京军区总医院

中国循证心血管医学杂志

CSTPCD
影响因子：1.272
ISSN：1674-4055
参考文献量16
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