NLR、SII与老年急性冠脉综合征患者直接介入术后对比剂肾病的相关性
Correlation among neutrophil/lymphocyte ratio,systemic immune inflammation index and contrast-induced nephropathy in elderly patients with acute coronary syndrome after primary percutaneous coronary intervention
曹瑞 1冯俊2
作者信息
- 1. 233030 蚌埠,蚌埠医学院研究生院
- 2. 237000 六安,安徽医科大学附属六安市人民医院
- 折叠
摘要
目的 研究中性粒细胞与淋巴细胞比值(NLR)及全身免疫炎症指标(SII)与老年急性冠脉脉综合征(ACS)患者经皮冠状动介入治疗(PCI)术后对比剂肾病(CIN)的相关性.方法 选取2018年10月至2022年10月于六安市人民医院老年ACS行直接PCI患者231例,根据是否发生CIN,分为CIN组25例,非CIN组206例.回顾性分析纳入研究患者的基本资料,使用Logistic回归分析及受试者曲线(ROC)分析NLR及SII与CIN的相关性.结果 共有25例患者发生CIN(10.82%);CIN组高血压、糖尿病、射血分数＜40%、肾小球滤过率＜60%的发生率明显高于非CIN组(P＜0.05);CIN组的NLR、SII值明显高于非CIN组(P＜0.05).Logistic回归分析发现,NLR(OR=1.234,95%CI:1.096～1.388,P＜0.05)、SII(OR=1.001,95%CI:1.000～1.001,P＜0.05)与CIN的发生密切相关.受试者曲线(ROC)分析提示:NLR、SII联合预测CIN的曲线下面积是0.738(95%CI:0.632～0.845),约登指数0.443,灵敏度0.720,特异度0.723,有较高的预测价值.结论 NLR、SII水平与老年ACS患者PCI术后CIN的发生有显著相关性,可作为预测CIN发生的可靠标志物.
Abstract
Objective To study the correlation among neutrophil/lymphocyte ratio(NLR),systemic immune inflammation index(SII)and contrast-induced nephropathy(CIN)in elderly patients with acute coronary syndrome(ACS)after primary percutaneous coronary intervention(pPCI).Methods Elderly ACS patients(n=231)undergone pPCI were chosen from People's Hospital of Lu`an City from Oct.2018 to Oct.2022.All patients were divided,according to whether CIN occurred or not,into CIN group(n=25)and non-CIN group(n=206).The baseline materials of the patients were retrospectively analyzed.The correlation among NLR,SII and CIN was analyzed by using Logistic regression analysis and ROC curve analysis.Results There were totally 25 patients with CIN(10.82%).The percentages of patients with hypertension,diabetes,ejection fraction<40%and glomerular filtration rate(GFR)<60%were significantly higher in CIN group than those in non-CIN group(P<0.05).The value of NLR and SII were significantly higher in CIN group than those in non-CIN group(P<0.05).The results of Logistic regression analysis showed that NLR(OR=1.234,95%CI:1.096～1.388,P<0.05)and SII(OR=1.001,95%CI:1.000～1.001,P<0.05)were closely correlated to CIN occurrence.The results of ROC curve analysis showed that AUC of NLR combined with SII in predicting CIN was 0.738(95%CI:0.632～0.845),Jordan index was 0.443,sensitivity was 0.720 and specificity was 0.723.Conclusion The levels of NLR and SII are significantly correlated to CIN occurrence in elderly ACS patient after pPCI,which can be taken as reliable marks for predicting CIN occurrence.
关键词
急性冠脉综合征/经皮冠状动脉介入治疗/全身免疫炎症指标/对比剂肾病Key words
Acute coronary syndrome/Percutaneous coronary intervention/Systemic immune inflammation index/Contrast-induced nephropathy引用本文复制引用
基金项目
安徽省重点研发计划(1704f0804045)
安徽省六安市科技计划(2022lakj002)
安徽省六安市人民医院院级科研项目(2022kykt03)
出版年
2024
NETL
NSTL
维普
万方数据