碘克沙醇在STEMI患者急诊PCI术中应用的有效性和安全性
Efficacy and safety of iodixanol administrated during emergency PCI in patients with ST-segment elevation myocardial infarction
宋学莲 1刘立天 1于航维 1张飞飞 1王帆 1李英肖 1党懿1
作者信息
- 1. 050000 石家庄,河北省人民医院心血管内科
- 折叠
摘要
目的 探讨碘克沙醇在ST段抬高型心肌梗死(STEMI)患者急诊经皮冠状动脉介入治疗PCI)术中应用的有效性和安全性.方法 选取2020年1月至2020年12月于河北省人民医院收治的行急诊PCI的STEMI患者80例,根据术中应用的造影剂种类分为实验组(碘克沙醇)和对照组(碘佛醇),每组各40例.收集患者的基线资料,观察两组患者的血管影像质量、不良反应,记录术后48～72 h的血清肌酐(SCr)、估算的肾小球滤过率(eGFR).术后30 d随访,记录靶病变再次血运重建、卒中、支架内血栓、心源性死亡及心肌梗死等事件的发生.结果 两组患者临床基本资料无显著差异(P＞0.05),血管影像结果均清晰.两组间围手术期不良反应发生率、术前术后SCr、eGFR均无明显差异(P＞0.05),但对照组术后SCr水平较术前增高[(91.52±33.83)μmol/L vs.(76.89±16.89)μmol/L,P＜0.05],而实验组SCr水平无明显变化.结论 碘克沙醇在STEMI患者急诊PCI术中对肾功能影响较小,更为安全.
Abstract
Objective To discuss the efficacy and safety of iodixanol administrated during emergency percutaneous coronary intervention(PCI)in patients with ST-segment elevation myocardial infarction(STEMI).Methods STEMI patients(n=80)undergone emergency PCI were chosen from People's Hospital of Hebei Province from Jan.2020 to Dec.2020,and divided,according to contrast agent types,into test group(given iodixanol)and control group(given ioversol,each n=40).The baseline materials were collected from the patients,the quality of vascular imaging and adverse reactions were observed,and serum creatinine(SCr)and estimated glomerular filtration rate(eGFR)from 48 h to 72 h after the operation were recorded in 2 group.The patients were followed up 30 d after the operation,and incidence of targe lesion events were recorded including revascularization,stroke,in-stent thrombosis,cardiac death and myocardial infarction(MI).Results The clinical baseline materials had no significant difference between 2 groups(P>0.05),and results of vascular imaging were clear in 2 groups.The incidence rates of perioperative adverse reactions and levels of SCr and eGFR had no significant differences between 2 groups(P>0.05),but postoperative SCr increased[(91.52±33.83)μmol/L vs.(76.89±16.89)μmol/L,P<0.05]in control group,and had no significant changes in test group.Conclusion Iodixanol has less effect on kidney function and is safer in STEMI patients during emergency PCI.
关键词
ST段抬高型心肌梗死/急诊经皮冠状动脉介入治疗/碘克沙醇Key words
ST-segment elevation myocardial infarction/Emergency percutaneous coronary intervention/Iodixanol引用本文复制引用
基金项目
河北省医学科学研究项目(20200729)
出版年
2024
NETL
NSTL
维普
万方数据