瓜蒌薤白半夏汤对冠心病心绞痛患者PCI术后心肌损伤标志物水平的影响
Influence of Gualou Xiebai Banxia Tang on levels of myocardial injury biomarkers in patients with coronary heart disease-angina pectoris after PCI
王辉 1姜爱华2
作者信息
- 1. 071051 保定,保定市第三中心医院心内科
- 2. 071000 保定,保定市第一中心医院心内科
- 折叠
摘要
目的 探讨瓜蒌薤白半夏汤对冠状动脉粥样硬化性心脏病(冠心病)心绞痛患者经皮冠状动脉介入治疗(PCI)术后心肌损伤标志物水平的影响.方法 选取2022年1月～2023年2月于保定市第一中心医院心内科行PCI的冠心病心绞痛患者98例,随机分为观察组和对照组,每组各49例.对照组术后给予常规西药治疗,观察组在对照组的基础上加用瓜蒌薤白半夏汤.比较两组患者临床疗效、中医证候积分、心肌损伤标志物[肌酸激酶同工酶(CK-MB)、肌钙蛋白T(cTnT)、肌红蛋白(MB)]、生活质量[西雅图心绞痛量表(SAQ)评定]和不良反应率.结果 治疗4周后,观察组患者临床疗效高于对照组(P＞0.05);两组患者中医证候积分均低于同组治疗前(P＜0.05),且观察组低于对照组(P＜0.05).治疗4周后,两组患者CK-MB、cTnT、MB水平均低于同组治疗前(P＜0.05),且观察组低于对照组(P＜0.05).治疗4周后,两组患者SAQ各项评分均高于同组治疗前(P＜0.05),且观察组高于对照组(P＜0.05).两组患者不良反应率比较无统计学差异(P＞0.05).结论 瓜蒌薤白半夏汤可改善冠心病心绞痛患者PCI术后的临床症状,具有减轻心肌损伤、保护心肌的作用.
Abstract
Objective To discuss the influence of Gualou Xiebai Banxia Tang on levels of myocardial injury biomarkers in patients with coronary heart disease-angina pectoris(CHD-AP)after percutaneous coronary intervention(PCI).Methods CHD-AP patients(n=98)undergone PCI were chosen from Department of Cardiology in the First Central Hospital of Baoding City from Jan.2022 to Feb.2023,and they were randomly divided into observation group and control group(each n=49).After PCI,control group was given routine Western drugs and observation group was additionally given Gualou Xiebai Banxia Tang.The clinical efficacy,integrals of TCM syndrome,myocardial injury biomarkers[creatine kinase-MB isoenzyme(CK-MB),cardiac troponin T(cTnT),myoglobin(MB)],quality of life[QOL assessed by using Seattle Angina Questionnaire(SAQ)]and incidence of adverse reactions were compared between 2 groups.Results After treatment for 4 weeks,clinical efficacy was higher in observation group than that in control group(P>0.05).The integrals of TCM syndrome were lower in 2 groups than before treatment(P<0.05),and was lower in observation group than that in control group(P<0.05).After treatment for 4 weeks,the levels of CK-MB,cTnT and MB were lower in 2 groups than before treatment(P<0.05),and were lower in observation group than those in control group(P<0.05).The scores of SAQ were higher in 2 groups than before treatment(P<0.05),and were higher in observation group than those in control group(P<0.05).The comparison in incidence of adverse reactions had no statistical differences between 2 groups(P>0.05).Conclusion Gualou Xiebai Banxia Tang can relieve clinical symptoms with effects of ameliorating myocardial injury and protecting myocardium in CHD-AP patients after PCI.
关键词
经皮冠状动脉介入治疗/心肌损伤标志物/瓜蒌薤白半夏汤Key words
Percutaneous coronary intervention/Myocardial injury biomarkers/Gualou Xiebai Banxia Tang引用本文复制引用
基金项目
河北省自然科学基金(H2021206176)
出版年
2024
NETL
NSTL
维普
万方数据