冠心病患者外周血miR-126水平与PCI术后支架内再狭窄、血清hs-CRP及sVCAM-1水平的关系
Relationship among miR-126,in-stent restenosis,high sensitivity C-reactive protein and soluble vascular cell adhesion molecules-1 in patients with coronary heart disease after PCI
董芊汝 1赵紫楠 2张亚同 2王婷婷 1付坤 1王蓉 1陆蕙 1王进1
作者信息
- 1. 100076 北京,北京航天总医院心内二科
- 2. 100730 北京,北京医院药学部 国家老年医学中心 中国医学科学院老年医学研究院北京市药物临床风险与个体化应用评价重点实验室(北京医院)
- 折叠
摘要
目的 分析冠状动脉粥样硬化性心脏病(冠心病)患者外周血miR-126水平与经皮冠状动脉介入治疗(PCI)术后支架内再狭窄(ISR)、血清超敏C反应蛋白(hs-CRP)及可溶性血管细胞黏附分子-1(sVCAM-1)水平的关系.方法 选取2021年2月至2022年2月于北京航天总医院收治的冠心病患者103例(病例组),所有患者均接受PCI.病例组中急性心肌梗死32例(AMI组),不稳定型心绞痛42例(UAP组),稳定型心绞痛29例(SAP组),另选取同期50例非冠心病的健康体检者作为对照组.分别检测外周血miR-126、hs-CRP、sVCAM-1水平及PCI术后ISR的发生情况,分析miR-126水平与PCI术后支架内再狭窄、hs-CRP及sVCAM-1水平的相关性.结果 病例组的miR-126表达水平明显低于对照组,hs-CRP、sVCAM-1表达水平明显高于对照组(P＜0.05);三组不同类型冠心病患者的miR-126、hs-CRP、sVCAM-1水平比较,差异有统计学意义(P＜0.05).AMI组的miR-126表达水平明显低于UAP组和SAP组(P＜0.05),UAP组的miR-126表达水平明显低于SAP组(P＜0.05),AMI组的hs-CRP、sVCAM-1表达水平明显高于UAP组和SAP组(P＜0.05).UAP组的hs-CRP、sVCAM-1表达水平明显高于SAP组(P＜0.05);ISR组的miR-126表达水平明显低于未ISR组,hs-CRP、sVCAM-1表达水平明显高于未ISR组(P＜0.05).冠心病患者miR-126水平与hs-CRP、sVCAM-1水平均呈明显负相关(P＜0.05),hs-CRP水平与sVCAM-1水平呈明显正相关(P＜0.05).结论 miR-126水平与冠心病患者PCI术后ISR密切相关,可能通过患者的炎症反应、动脉粥样硬化促进PCI术后ISR的发生.
Abstract
Objective To analyze the relationship among peripheral blood miR-126,in-stent restenosis(ISR),high sensitivity C-reactive protein(hs-CRP)and soluble vascular cell adhesion molecules-1(sVCAM-1)in patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods CHD patients(n=103,case group)undergone PCI were chosen from Beijing Aerospace General Hospital from Feb.2021 to Feb.2022.The case group was divided into acute myocardial infarction group(AMI group,n=32),unstable angina pectoris group(UAP group,n=42)and stable angina pectoris group(SAP group,n=29),and also divided into ISR group and non-ISR group according to ISR occurrence status after PCI.In addition,the cases without CHD with healthy examinations were chosen into control group(n=50).The levels of peripheral blood miR-126,hs-CRP and sVCAM-1 were detected,and ISR occurrence after PCI was observed.The correlation among miR-126 level,in-stent restenosis after PCI,and levels of hs-CRP and sVCAM-1 was analyzed.Results The level of miR-126 was significantly lower,and levels of hs-CRP and sVCAM-1 were significantly higher in case group than those in control group(P<0.05).The comparison in levels of miR-126,hs-CRP and sVCAM-1 showed statistical significance among AMI group,UAP group and SAP group(P<0.05).The level of miR-126 was significantly lower in AMI group than that in UAP group and SAP group(P<0.05),and significantly lower in UAP group than that in SAP group(P<0.05).The levels of hs-CRP and sVCAM-1 were significantly higher in AMI group than those in UAP group and SAP group(P<0.05),and significantly higher in UAP group than that in SAP group(P<0.05).The level of miR-126 was significantly lower,and levels of hs-CRP and sVCAM-1 were significantly higher in ISR group than those in non-ISR group(P<0.05).The level of miR-126 was negatively correlation to levels of hs-CRP and sVCAM-1 significantly in CHD patients(P<0.05).The level of hs-CRP was positively correlated to sVCAM-1 level significantly in CHD patients(P<0.05).Conclusion The level of miR-126 is closely correlated to ISR in CHD patients after PCI,and ISR may be improved through inflammatory responses and atherosclerosis.
关键词
冠状动脉粥样硬化性心脏病/经皮冠状动脉介入治疗/支架内再狭窄/超敏C反应蛋白/可溶性血管细胞黏附分子-1Key words
Coronary heart disease/Percutaneous coronary intervention/In-stent restenosis/High sensitivity C-reactive protein/Soluble vascular cell adhesion molecules-1引用本文复制引用
基金项目
国家重点研发计划(2020YFC2009001)
出版年
2024
NETL
NSTL
万方数据