慢性心力衰竭患者血清CTGF、SIRT1表达及与心肌重构的相关性研究
Correlation among expressions of serum CTGF,SIRT1 and myocardial remodeling in patients with chronic heart failure
王姣 1李慧云 1苑柳翠1
作者信息
摘要
目的 观察慢性心力衰竭(心衰)患者血清结缔组织生长因子(CTGF)、沉默信息调节因子1(SIRT1)的表达,并分析其与心肌重构的相关性.方法 选择2022年1月至2023年5月于青岛市市立医院收治的120例慢性心衰患者作为观察组,美国纽约心脏病协会(NYHA)心功能分级Ⅱ级38例、Ⅲ级57例、Ⅳ级25例,并选择同期体检中心的100例健康志愿者作为对照组.比较两组不同心功能分级患者血清CTGF、SIRT1、心肌重构指标[左室舒张末期内径(LVEDD)、左心房内径(LAD)、左心室后壁厚度(LVPWD)、左心室质量指数(LVMI)、左心室重构指数(LVRI)]的表达,并分析血清CTGF、SIRT1与心肌重构指标的相关性.结果 与对照组相比,观察组血清CTGF、LVEDD、LAD、LVPWD、LVMI、LVRI均更高,血清SIRT1更低(P＜0.05);随着心功能分级增加,血清CTGF、LVEDD、LAD、LVPWD、LVMI、LVRI均升高,血清SIRT1降低,有统计学意义(P＜0.05);Pearson相关性分析显示,血清CTGF、SIRT1与心肌重构指标均具有相关性(P＜0.05).结论 慢性心衰患者血清CTGF升高,SIRT1水平降低,且与心肌重构存在密切关系,
Abstract
Objective To observe the expressions of serum connective tissue growth factor(CTGF)and silent information regulator 1(SIRT1),and analyze the correlation among the expressions and myocardial remodeling in patients with chronic heart failure(CHF).Methods CHF patients(n=120)were chosen into observation group from Qingdao Municipal Hospital from Jan.2022 to May 2023.According to NYHA classification of heart function,the patients in observation group were divided into grade Ⅱ subgroup(n=38),grade Ⅲ subgroup(n=57)and grade Ⅳsubgroup(n=25).At the same time,healthy volunteers(n=100)were chosen into control group.The expressions of serum CTGF and SIRT1,and indexes of myocardial remodeling[left ventricular end-diastolic diameter(LVEDD),left atrial diameter(LAD),left ventricular posterior wall thickness(LVPWT),left ventricular mass index(LVMI)and left ventricular remodeling index(LVRI)]were compared between observation and control group,and among all subgroups.The correlation among CTGF,SIRT1 and myocardial remodeling index were analyzed.Results Compared with control group,CTGF,LVEDD,LAD,LVPWD,LVMI and LVRI were higher,and SIRT1 was lower in observation group(P<0.05).With the increase of heart function grade,CTGF,LVEDD,LAD,LVPWD,LVMI and LVRI increased,and SIRT1 decreased(P<0.05).The results of Pearson correlation analysis showed that CTGF and SIRT1 were correlated to indexes of myocardial remodeling(P<0.05).Conclusion The expression of CTGF increases and SIRT1 expression decreased,and are closely correlated to myocardial remodeling in CHF patients.
关键词
慢性心力衰竭/心肌重构/结缔组织生长因子/沉默信息调节因子1Key words
Chronic heart failure/Myocardial remodeling/Connective tissue growth factor/Silent information regulator 1引用本文复制引用
出版年
2024
NETL
NSTL
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