Correlation between heart rate recovery after exercise and risk of sudden cardiac death:a Meta-analysis of cohort studies
王晨阳 1徐鹏 1郭治荣 2王冬颖 1李俊峡 3曹雪滨1
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作者信息
1. 071000 保定,中国人民解放军陆军第八十二集团军医院心内科
2. 071000 保定,中国人民解放军陆军第八十二集团军医院卫勤处
3. 100700 北京,中国人民解放军总医院第七医学中心心内科
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摘要
目的 通过Meta分析,综合分析运动后心率恢复(HRR)与心源性猝死(SCD)之间的关系.方法 基于PubMed、Embase和Web of Science数据库,进行截至2024年1月2日的文献检索.队列研究关注于HRR和SCD间的风险关系,通过风险比(HR)及95％可信区间(CI)进行评估.统计学分析采用Stata12.0软件.结果 纳入6项研究.固定效应模型(I2=41.8％,P=0.112)的汇总结果显示:与心率恢复慢相比,心率恢复快人群发生SCD风险更低(HR=0.74,95％CI:0.64～0.86,P＜0.001).大多数亚组分析中都观察到了持续结果.排除一项研究并不影响总体结果[HR(95％CI):0.66(0.55,0.79)～0.76(0.65,0.88)].Egger检验未发现明显的发表偏倚(P=0.059).结论 心率恢复较慢会增加普通人群发生SCD的风险.因此,HRR可能是临床实践中预防SCD的一个潜在靶点.
Abstract
Objective To analyze comprehensively the correlation between heart rate recovery(HRR)after exercise and risk of sudden cardiac death(SCD)through a Meta-analysis.Methods The databases of PubMed,EMbase and Web of Science were retrieved up to Jan.2,2024.The cohort studies focused on the risk correlation between HRR and SCD,which was reviewed based on hazard ratio(HR)and 95％confidence interval(95％CI).All statistical analyses were conducted by using Stata 12.0 software.Results There were totally 6 studies included.The pooled results of fixed-effects model analysis(I2=41.8％,P=0.112)showed that SCD risk was lower in the patients with faster HRR than that in those with slower HRR(HR=0.74,95％CI:0.64～0.86,P＜0.001).The persistent results were observed in most subgroup analyses.After excluded a study,the overall result was not affected[HR(95％CI):0.66(0.55,0.79)to 0.76(0.65,0.88)].The results of Egger test showed that there was no significant publication bias(P=0.059).Conclusion The slower HRR can increase SCD risk,so HRR may be a potential target for SCD prevention in clinical practice.
关键词
心源性猝死/运动后心率恢复/荟萃分析/风险相关性
Key words
Sudden cardiac death/Heart rate recovery after exercise/Meta-analysis/Risk correlation
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