Objective To review systematically the efficacy and safety of Qishen Yiqi Gutta Pills in treating coronary heart disease-angina pectoris(CHD-AP).Methods There were totally 7 Chinese and English databases retrieved for collecting randomized controlled trials(RCT)of treating CHD-AP with Qishen Yiqi Gutta Pills from database establishment time to Jan.1,2023.The collected RCT were given a Meta-analysis by using RevMan5.4.1 software.Results There were totally 17 RCT included involved 1817 subjects.Compared with control group(treated with routine Western medicine),in treatment group(treated with Qishen Yiqi Gutta Pills and routine Western medicine),the curative effects on TCM syndromes(OR=6.43,95％CI:4.17～9.90,P＜0.00001),electrocardiogram(OR=3.04,95％CI:2.08～4.44,P＜0.00001)and the total integrals of TCM symptoms(MD=-3.49,95％CI:-3.98～-3.00,P＜0.00001),and scores of PL,AS,AF,TS and DP in Seattle Angina Questionnaire(SAQ)were improved,hs-CRP level(MD=-1.88,95％CI:-2.81～-0.96,P＜0.0001)was reduced,and LVEF level was promoted(MD=2.53,95％CI:0.76～4.30,P=0.005).The results of subgroup analysis showed that Qishen Yiqi Gutta Pills had a higher curative effect on LVEF improvement(MD=2.53,95％CI:0.76～4.30,P=0.005,I2=83％)after treatment for 6 months.There were no severe adverse reactions in both 2 groups,and no significant difference in safety between 2 groups.Conclusion Qishen Yiqi Gutta Pills combined with routine Western medicine has a higher clinical efficacy on CHD-AP without severe adverse reactions,but the above conclusion needs to be further verified by more high-quality studies.
维普
万方数据