摘要
目的 分析1990～2019年中国和全球居民归因于Ω-3多不饱和脂肪酸(Ω3-PUFA)摄入不足的缺血性心脏病(IHD)疾病负担及变化情况.方法 利用2019年全球疾病负担数据,选取年龄标化死亡率、标化伤残调整寿命年(DALY)率和平均年度百分比变化率(AAPC)等指标,对1990～2019年中国和全球居民归因疾病负担状况及变化趋势进行分析.结果 2019年中国居民归因于Ω3-PUFA摄入不足的IHD标化死亡率为4.32/10万,标化DALY率为75.93/10万;而全球归因标化死亡率和DALY率分别为4.32/10万和90.65/10万.与1990年相比,2019年中国归因于Ω3-PUFA摄入不足的IHD标化死亡率升高12.88％,DALY率降低3.58％;而全球归因标化死亡率和DALYs率均较1990年下降,分别降低31.10％和28.74％.2019年中国归因标化死亡率和DALY率均表现为男性高于女性(5.77/10万vs.3.36/10万、102.10/10万vs.53.52/10万),且均随年龄增长而升高.1990～2019年,中国归因疾病负担整体呈先上升后下降趋势,归因标化死亡率AAPC为0.4％(95％CI:0.2％～0.6％,P＜0.05),而DALY率AAPC为-0.1％(95％CI:-0.3％～0％),P＜0.05).结论 在全球Ω3-PUFA摄入不足所致IHD疾病负担明显下降的背景下,中国在控制相关疾病负担方面仍有不足.适当补充Ω3-PUFA可能改善IHD疾病负担.
Abstract
Objective To study the burden and trend of ischemic heart disease(IHD)attributed to insufficient omega-3 polyunsaturated fatty acids(Ω3-PUFA)in China and the World from 1990 to 2019.Method Based on the data of 2019 global burden of disease,the age-standardized mortality rate,age-standardized disability-adjusted life year(DALY)rate,and annual average percentage change(AAPC)were used to analyze the status and trend of attributable disease burden in China and the World from 1990 to 2019.Results In 2019,the age-standardized mortality rate of IHD attributed to insufficient intake of Ω3-PUFA in Chinese residents was 4.32/100,000,and the standardized DALY rate was 75.93/100,000,while the global attributable standardized mortality rate and standardized DALY rate were 4.32/100,000 and 90.65/100,000,respectively.Compared with 1990,the standardized mortality rate of IHD attributed to insufficient intake of Ω3-PUFA in 2019 in China increased by 12.88％,while the standardized DALY rate decreased by 3.58％.At the global level,both the attributable standardized mortality rate and the standardized DALY rate in 2019 showed a downward trend compared with 1990,by 31.10％and 28.74％,respectively.In 2019,the attributable standardized mortality and DALY rate in China were higher in males than in females(5.77/100,000 vs.3.36/100,000,102.10/100,000 vs.53.52/100,000),and both showed an upward trend with age.From 1990 to 2019,the disease burden of IHD attributed to insufficient intake of Ω3-PUFA in China increased at first and then decreased;the AAPC of attributable standardized mortality rate in China was 0.4％(95％CI:0.2％-0.6％,P＜0.05),and the AAPC of attributable standardized DALY rate was-0.1％(95％CI:-0.3％-0％,P＜0.05).Conclusion Compared with the current situation where the IHD disease burden caused by insufficient Ω 3-PUFA intake in the world is significantly reduced,China still has deficiencies in controlling the related disease burden.Proper supplement of Ω3-PUFA may improve the disease burden of IHD.
基金项目
国家自然科学基金(82100292)
国家级大学生创新创业训练计划项目(202110486083)
国家级大学生创新创业训练计划项目(202210486116)
维普
万方数据