Allisartan Tablet in treating hypertensive retinal arteriosclerosis and its influence on vascular endothelial function,high mobility group box-1 protein,endogenous ligand of hypothalamic growth hormone secretin receptor and β2-microglobulin
Allisartan Tablet in treating hypertensive retinal arteriosclerosis and its influence on vascular endothelial function,high mobility group box-1 protein,endogenous ligand of hypothalamic growth hormone secretin receptor and β2-microglobulin
Objective To investigate Allisartan Tablet in treating hypertensive retinal arteriosclerosis(HRA)and its influence on vascular endothelial function,high mobility group box-1 protein(HMGB1),endogenous ligand of hypothalamic growth hormone secretin receptor(Ghrelin)and β2-microglobulin(β2-MG).Methods HRA patients(n=320)were retrospectively chosen from Hebei Petro China Central Hospital from Jan.2017 to Dec.2020,and then divided into test group and control group(each n=160)according to random digital table.The test group was treated with Allisartan Tablet and control group was treated with Nifedipine Tablet.The indexes of blood pressure including systolic blood pressure(SBP)and diastolic blood pressure(DBP),grading of retinal arteriosclerosis(RA),indexes of vascular endothelial function including vascular endothelial growth factor(VEGF),nitric oxide(NO)and endothelin-1(ET-1),levels of serum HMGB1,Ghrelin and β2-MG,and adverse reactions were observed in 2 groups before treatment and after treatment for 6 months.Results After treatment for 6 months,the levels of SBP[(120.65±15.62)mmHg vs.(137.76±16.14)mmHg]and DBP[(86.76±9.15)mmHg vs.(92.05±9.43)mmHg]were lower in test group than those in control group(P＜0.05).The proportion of higher Scheie angle grade was lower in test group than that in control group(P＜0.05).The levels of serum VEGF[(32.08±3.42)ng/L vs.(27.64±2.93)ng/L]and NO[(30.35±3.31)μ mol/L vs.(26.05±2.88)μ mol/L]were higher in test group than those in control group,and The levels of serum ET-1[(84.65±8.63)ng/L vs.(91.50±9.36)ng/L],HMGB1[(301.64±32.39)pg/ml vs.(346.17±36.50)pg/ml],Ghrelin[(11.86±1.37)pg/ml vs.(16.25±1.90)pg/ml]andβ 2-MG[(1.79±0.19)mg/L vs.(2.11±0.23)mg/L]were lower in test group than those in control group(P＜0.05).The incidence of adverse reactions had no difference between 2 groups(P＞0.05).Conclusion Allisartan Tablet,in HRA treatment,can effectively control blood pressure,improve vascular endothelial function,reduce RA grade,and inhibit generation of HMGB1,Ghrelin and β2-MG.
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