Expressions and influence on prognosis of serum secreted frizzled-related protein-5 and clusterin in patients with acute myocardial infarction after percutaneous coronary intervention
Expressions and influence on prognosis of serum secreted frizzled-related protein-5 and clusterin in patients with acute myocardial infarction after percutaneous coronary intervention
Objective To investigate the expressions and influence on prognosis of serum secreted frizzled-related protein-5(SFRP5)and clusterin(CLU)in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods AMI patients(n=80)were chosen into observation group and meanwhile healthy subjects(n=80)were chosen into control group from Department of Cardiology in People's Hospital of Shehong City from Mar.2022 to Mar.2023.The levels of serum SFRP5 and CLU were compared between 2 groups and among patients with different heart function grades and different prognosis.The correlation among levels of serum SFRP5 and CLU and prognosis was analyzed by using Pearson correlation analysis in AMI patients after PCI.Results The level of SFRP5 was lower and level of CLU was higher in observation group than those in control group(P＜0.05).In observation group,SFRP5 level was lower and CLU level was higher in patients with grades Ⅲ～Ⅳ of NYHA classification than that in patients with grades Ⅰ～Ⅱ of NYHA classification(P＜0.05).The level of SFRP5 was lower and level of CLU was higher in poor prognosis group than those in good prognosis group(P＜0.05).The results of Pearson correlation analysis showed that SFRP5 level was negatively correlated to prognosis and CLU level was positively correlated to prognosis(P＜0.05)in AMI patients after PCI.Conclusion The expressions of SFRP5 and CLU are closely correlated to prognosis in AMI patients after PCI.The monitoring of SFRP5 and CLU expressions can provide important reference for precise treatment and prognosis assessment in AMI patients.
维普
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