中国循证心血管医学杂志2024，Vol.16Issue(7) ：782-784,817.DOI:10.3969/j.issn.1674-4055.2024.07.04

早发冠心病患者发病的危险因素及RLP-C、AIP对短期预后的预测价值

Predisposing risk factors and predictive value of remnant-like lipoprotein-cholesteroland atherogenic index of plasma to short-term prognosis in patients with premature coronary artery disease

段文娟 任保军 崔国峰 武云涛
中国循证心血管医学杂志2024，Vol.16Issue(7) ：782-784,817.DOI:10.3969/j.issn.1674-4055.2024.07.04
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  • 维普
  • 万方数据

早发冠心病患者发病的危险因素及RLP-C、AIP对短期预后的预测价值

Predisposing risk factors and predictive value of remnant-like lipoprotein-cholesteroland atherogenic index of plasma to short-term prognosis in patients with premature coronary artery disease

段文娟 1任保军 2崔国峰 2武云涛3
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作者信息

  • 1. 010050 呼和浩特,内蒙古医科大学附属医院康复医学科
  • 2. 010050 呼和浩特,内蒙古医科大学附属医院心血管内科
  • 3. 100700 北京,解放军总医院第七医学中心老年医学科
  • 折叠

摘要

目的 探讨早发冠状动脉粥样硬化性心脏病(冠心病)患者发病的危险因素及残粒样脂蛋白-胆固醇(RLP-C)、血浆致动脉粥样硬化指数(AIP)对短期预后的预测价值.方法 回顾性分析2022年1月至2024年1月于内蒙古医科大学附属医院就诊的120例早发冠心病患者作为观察组,另选择同期本院体检的健康人群100例作为对照组.分析早发冠心病患者发病的危险因素,并比较观察组不同预后患者RLP-C、AIP水平,采用受试者工作曲线(ROC)分析RLP-C、AIP及联合检测对早发冠心病患者短期预后的预测价值.结果 多因素Logistic回归分析显示,体质指数(BMI)、高血压、吸烟、冠心病家族史、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、RLP-C、AIP均是早发冠心病患者发病的危险因素(P＜0.05).随访6个月,观察组预后不良组11例、预后良好组109例,预后不良组RLP-C、AIP均高于预后良好组,差异有统计学意义(P＜0.05).ROC分析显示,RLP-C、AIP联合检测对早发冠心病患者短期预后的预测价值[曲线下面积(AUC):0.992,95％CI:0.981～1.000]均高于RLP-C(AUC:0.927,95％CI:0.862～0.993)、AIP(AUC:0.982,95％CI:0.955～1.000)单独检测.结论 早发冠心病患者发病的危险因素较多,且RLP-C、AIP联合检测对患者短期预后具有较好的预测价值.

Abstract

Objective To investigate the predisposing risk factors and predictive value of remnant-like lipoprotein-cholesterol(RLP-C)and atherogenic index of plasma(AIP)to short-term prognosis in patients with premature coronary artery disease(PC AD).Methods PC AD patients(n=120)were retrospectively chosen into observation group and healthy controls were chosen into control group(n=100)from Affiliated Hospital of Inner Mongolia Medical University from Jan.2022 to Jan.2024.The predisposing risk factors for PCAD were analyzed,and levels of RLP-C and AIP were compared in patients with different prognosis in observation group.The predictive value of RLP-C,AIP and combination of RLP-C and AIP to short-term prognosis in PCAD patients were analyzed by using ROC curve.Results The results of multi-factor Logistic regression analysis showed that body mass index(BMI),hypertension,smoking,family history of coronary heart disease(CHD),triglyceride(TG),total cholesterol(TC),high-density lipoprotein-cholesterol(HDL-C),low-density lipoprotein-cholesterol(LDL-C),RLP-C and AIP all were predisposing risk factors for PCAD(P＜0.05).After followed up for 6 months,there were 11 patients in poor prognosis group and 109 in good prognosis group in observation group.The levels of RLP-C and AIP were higher in poor prognosis group than those in good prognosis group(P＜0.05).The results of ROC curve analysis showed that the predictive value of combination of RLP-C and AIP(AUC=0.992,95％CI:0.981～1.000)were higher than that of only RLP-C(AUC=0.927,95％CI:0.862-0.993)or only AIP(AUC=0.982,95％CI:0.955～1.000)in detecting short-term prognosis in PCAD patients.Conclusion There are many predisposing risk factors for PCAD,and combination of RLP-C and AIP has a higher predictive value in detecting short-term prognosis in PCAD patients.

关键词

早发冠心病/残粒样脂蛋白-胆固醇/致动脉粥样硬化指数/预后

Key words

Premature coronary artery disease/Remnant-like lipoprotein-cholesterol/Atherogenic index of plasma/Prognosis

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出版年

2024
中国循证心血管医学杂志
中国人民解放军北京军区总医院

中国循证心血管医学杂志

CSTPCD
影响因子：1.272
ISSN：1674-4055
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