中国循证心血管医学杂志2024，Vol.16Issue(7) ：818-821.DOI:10.3969/j.issn.1674-4055.2024.07.13

血清miR-138-5p,SORBS2水平与老年冠心病患者斑块稳定性及病变程度的相关性研究

Correlation among levels of serum miR-138-5p and SORS2,plaque stability and lesion severity in elderly patients with coronary heart disease

高阿芳 郑梅 胡钦
中国循证心血管医学杂志2024，Vol.16Issue(7) ：818-821.DOI:10.3969/j.issn.1674-4055.2024.07.13
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  • 维普
  • 万方数据

血清miR-138-5p,SORBS2水平与老年冠心病患者斑块稳定性及病变程度的相关性研究

Correlation among levels of serum miR-138-5p and SORS2,plaque stability and lesion severity in elderly patients with coronary heart disease

高阿芳 1郑梅 1胡钦1
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作者信息

  • 1. 050001 石家庄,石家庄市人民医院心内科
  • 折叠

摘要

目的 探讨血清微小RNA-138-5p(miR-138-5p)、Sorbin和SH3结构域连接蛋白2(SORBS2)水平与老年冠状动脉粥样硬化性心脏病(冠心病)患者斑块稳定性及病变程度的相关性.方法 取2022年7月至2024年1月于石家庄市人民医院收治的131例老年冠心病患者,根据超声结果确定血管腔内的斑块情况分为稳定组52例和不稳定组79例;根据冠状动脉造影结果进行Gensini评分,结合病变范围分为单支病变组42例,双支病变组46例和三支病变组43例.另外选取同期在本院进行体检的49例健康者作为对照组.采用实时荧光定量聚合酶链反应(qRT-PCR)对两组血清miR-138-5p和SORBS2水平检测,采用Pearson法和Spearman法分析血清miR-138-5p和SORBS2水平与老年冠心病患者斑块稳定性及病变程度相关性.结果 不稳定组血清miR-138-5p低于稳定组、对照组,且稳定组低于对照组.不稳定组血清SORBS2高于稳定组和对照组,且稳定组高于对照组(P＜0.05).Pearson法分析结果显示,老年冠心病患者血清miR-138-5p水平与SORBS2水平呈负相关(P＜0.05).高密度脂蛋白胆固醇(HDL-C)、血清miR-138-5p水平是老年冠心病患者不稳定斑块形成的保护因素,三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、血清SORBS2水平是老年冠心病患者不稳定斑块形成的危险因素(P＜0.05).与单支病变组相比,双支病变组、三支病变组患者血清miR-138-5p水平降低,其中三支病变组降低更显著(P＜0.05),血清SORBS2水平、Gensini评分升高,其中三支病变组升高更多(P＜0.05).Spearman相关性分析结果显示,老年冠心病患者血清miR-138-5p水平与Gensini评分呈负相关,血清SORBS2水平与Gensini评分呈正相关.结论 血清miR-138-5p和SORBS2水平与老年冠心病患者斑块稳定性及病变程度密切相关.

Abstract

Objective To investigate the correlation among levels of serum microRNA-138-5p(miR-138-5p)andSorbin and SH3 domain-containing protein 2(SORS2),plaque stability and lesion severity in elderly patients with coronary heart disease(CHD).Methods Elderly CHD patients(n=131)were chosen and divided,according to plaque situation determined by ultrasound results,into stable group(n=52)and unstable group(n=79)from July 2022 and Jan.2024.According to results of coronary angiography(CAG),Gensini scores andlesion extent,the patients were divided into single-vessel lesion group(n=42),double-vessel lesion group(n=46)and triple-vessel lesion group(n=43).In addition,healthy controls(n=49)were chosen into control group.The levels of serum miR-138-5p and SORBS2 were detected by using qRT-PCR,and correlation among miR-138-5p,SORBS2,plaque stability and lesion severity were analyzed by using Pearson method and Spearman method.Results The level of miR-138-5p was lower and level of ORBS2 was higher in unstable group than those in stable group and control group,which were more significant in stable group(P＜0.05).The results of Pearson method showed that miR-138-5p level was negatively correlated to SORBS2 level(P＜0.05).The levels of high-density lipoprotein-cholesterol(HDL-C)and miR-138-5p level were protective factors for unstable plaque formation,and levels of triglyceride(TG),low-density lipoprotein-cholesterol(LDL-C)and SORBS2 level were risk factors for unstable plaque formation(P＜0.05)in elderly CHD patients.The level of miR-138-5p decreased,and SORBS2 level and Gensini scores increased in double-vessel lesion group and triple-vessel lesion group compared with single-vessel lesion group,which were more significantly in triple-vessel lesion group(P＜0.05,P＜0.05).The results of Spearman correlation analysis showed that miR-138-5p level was negatively correlated to Gensini scores,and SORBS2 level was positively correlated to Gensini scores.Conclusion The levels of serum miR-138-5p and SORS2 are closely correlated to plaque stability and lesion severity in elderly CHD patients.

关键词

冠状动脉粥样硬化性心脏病/微小RNA-138-5p/Sorbin和SH3结构域连接蛋白2

Key words

Coronary heart disease/MicroRNA-138-5p/Sorbin and SH3 domain-containing protein 2

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出版年

2024
中国循证心血管医学杂志
中国人民解放军北京军区总医院

中国循证心血管医学杂志

CSTPCD
影响因子：1.272
ISSN：1674-4055
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