中国循证心血管医学杂志2024,Vol.16Issue(7) :822-825.DOI:10.3969/j.issn.1674-4055.2024.07.14

冠心病心房颤动血瘀证患者血清炎症趋化因子的研究

Study on serum inflammatory chemokines in patients with blood stasis syndrome of atrial fibrillation of coronary heart disease

陈婷 马振 李成龙 陈斌 陶涛 褚瑜光 胡元会
中国循证心血管医学杂志2024,Vol.16Issue(7) :822-825.DOI:10.3969/j.issn.1674-4055.2024.07.14

冠心病心房颤动血瘀证患者血清炎症趋化因子的研究

Study on serum inflammatory chemokines in patients with blood stasis syndrome of atrial fibrillation of coronary heart disease

陈婷 1马振 1李成龙 1陈斌 1陶涛 1褚瑜光 2胡元会2
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作者信息

  • 1. 710021 西安,西安市中医医院心内科
  • 2. 100053 北京,中国中医科学院广安门医院心内科
  • 折叠

摘要

目的 本研究以冠状动脉粥样硬化性心脏病(冠心病)心房颤动(房颤)血瘀证患者血清炎症趋化因子为主要切入点,主要研究血清炎症趋化因子在冠心病房颤血瘀证及非血瘀证患者血清中的差异.方法 选取2021年4月至2021年12月于中国中医科学院广安门医院就诊患者,收集并记录入组患者的年龄、性别、吸烟史、饮酒史、高血压、糖尿病、脑卒中史等一般资料,炎症趋化因子血清样本检测均采用用Luminex液相悬浮芯片实验技术.结果 冠心病房颤血瘀证组血清炎症趋化因子CXCL10、CXCL1平均浓度较冠心病房颤非血瘀证显著升高,CXCL10[172.12(143.00,345.92)]pg/ml vs.[110.58(90.53,142.89)]pg/ml、CXCL1[331.65(199.23,544.42)]pg/ml vs.[223.87(146.80,546.60)]pg/ml,差异有显著统计学意义(P<0.01).结论 炎症趋化因子CXCL1、CXCL10与冠心病房颤血瘀证存在一定相关性.

Abstract

Objective In this study,the serum inflammatory chemokines in patients with coronary heart disease(CHD)atrial fibrillation blood stasis syndrome were taken as the main entry point to study the difference of serum inflammatory chemokines in patients with CHD atrial fibrillation blood stasis syndrome and non-blood stasis syndrome.Methods Patients treated in Guang'anmen Hospital,China Academy of Traditional Chinese Medical Sciences from April 2021 to December 2021 were selected,and the general information of age,gender,smoking history,drinking history,hypertension,diabetes,stroke history and other general information were collected and recorded.Luminex liquid suspension chip technology was used to detect inflammatory chemokine serum samples.Results The mean concentration of CXCL10 and CXCL1 in serum inflammatory chemokines in CHD atrial fibrillation with blood stasis syndrome was significantly higher than in CHD atrial fibrillation without blood stasis syndrome.CXCL10[172.12(143.00,345.92)]pg/ml vs.[110.58(90.53,142.89)]pg/ml and CXCL1[331.65(199.23,544.42)]pg/ml vs.[223.87(146.80,546.60)]pg/ml,the difference was statistically significant(P<0.01).Conclusions CXCL1and CXCL10 have acertain correlation with blood stasis syndrome of coronary heart disease atrial fibrillation.

关键词

冠心病/心房颤动/血瘀证/血清炎症趋化因子

Key words

Coronary heart disease/Atrial fibrillation/Blood stasis/Serum inflammatory chemokines

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出版年

2024
中国循证心血管医学杂志
中国人民解放军北京军区总医院

中国循证心血管医学杂志

CSTPCD
影响因子:1.272
ISSN:1674-4055
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