Objective To analyze the predictive value of function of left atrial appendage(LAA)to ischemic stroke in patients with non-valvular persistent atrial fibrillation(PeAF).Methods The patients were received transesophageal echocardiography(TEE),computerized tomography(CT)or magnetic resonance imaging(MRI),diagnosed as PeAF and analyzed retrospectively in Department of Cardiovascular Medicine in People's Hospital of Liaocheng City from Jan.2019 to Dec.2021.The basic data and laboratory results were collected by using system of electronic medical record(EMR),and compared and analyzed.Results There were totally 263 patients included,aged from 30 to 85(mean age=59.06±9.097).The patients were divided into ischemic stroke group(IS group,n=70,mean age=64.46±8.70)and non-ischemic stroke(non-IS group,n=193,mean age=57.10±9.69).Age,cholesterol(CH),hypertension,and percentage of coronary heart disease(CHD)were significantly higher(P＜0.05),and low-density lipoprotein(LDL)and LA A peak emptying velocity were lower(P＜0.05)in IS group than those in non-IS group.The results of multi-factor Logistic regression analysis showed that LAA peak emptying velocity was negatively correlated to IS risk(P=0.002),and age and hypertension were positively correlated to IS risk(P＜0.05).The results of ROC curve analysis showed that the optimal cutoff value of LAA peak emptying velocity was 0.315 m/s in predicting IS,sensitivity was 65.7％,specificity was 67.2％and AUC was 0.686.Conclusion The decreased LAA peak emptying velocity,advanced age and hypertension are independent risk factors of IS in patients with non-valvularPeAF.Caution is warranted for IS occurrence when LAA peak emptying velocitydecreases to 0.315 m/s in patients with non-valvularPeAF.
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