Objective Atrial fibrillation has been associated with heart failure in observational studies.We performed a two-sample Mendelian randomization analysis to determine whether these associations were causal.Methods Single nucleotide polymorphisms(P＜5 × 10-8)were instrumental variables for atrial fibrillation and heart failure.Genetic association estimates for atrial fibrillation and heart failure were obtained from the Japan Biobank.MR-Egger regression,weighted median method(weight median estimator,WME),inverse variance weighted method(inverse-variance weighted,IVW),simple model,and weighted model were used for analysis.Results Genetically predicted atrial fibrillation was highly causally associated with heart failure.The results of Mendelian randomization showed that atrial fibrillation led to an increase in heart failure,the OR was 1.14(95％CI:1.10～1.17,P=0.34 ×109),and the heterogeneity test result P=0.24.Conclusions This study provides evidence of a causal relationship between AF and increased risk of heart failure,but the specific biological mechanisms require further investigation.
维普
万方数据