中国循证心血管医学杂志2024，Vol.16Issue(8) ：952-955.DOI:10.3969/j.issn.1674-4055.2024.08.10

川崎病患儿血清Cav-1、sLR11水平与冠状动脉病变严重程度的相关性分析

Correlation between levels of serum caveolin-1 and soluble low density lipoprotein receptor 11 and sever-ity of coronary artery lesions in child patients with Kawasaki disease

高建波 李娜 郑伟伟 许丽萍
中国循证心血管医学杂志2024，Vol.16Issue(8) ：952-955.DOI:10.3969/j.issn.1674-4055.2024.08.10
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  • 维普
  • 万方数据

川崎病患儿血清Cav-1、sLR11水平与冠状动脉病变严重程度的相关性分析

Correlation between levels of serum caveolin-1 and soluble low density lipoprotein receptor 11 and sever-ity of coronary artery lesions in child patients with Kawasaki disease

高建波 1李娜 1郑伟伟 1许丽萍2
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作者信息

  • 1. 459000 济源,河南省济源市人民医院儿科
  • 2. 451161 郑州,河南省儿童医院/郑州儿童医院
  • 折叠

摘要

目的 分析川崎病(KD)患儿血清小窝蛋白-1(Cav-1)、可溶性低密度脂蛋白受体11(sLR11)与冠状动脉病变(CAL)严重程度的关系.方法 回顾性分析2021年2月至2022年10月于济源市人民医院儿科收治的153例KD合并CAL患儿的临床资料.依据KD患儿CAL病变程度分为单支病变组(n=54)、双支病变组(n=68)和多支病变组(n=31).对比三组患儿临床资料、血清Cav-1、sLR11水平.Logistic多因素回归分析影响KD患儿CAL严重程度的相关因素.受试者工作特征曲线(ROC)分析血清Cav-1、sLR11对KD患儿CAL严重程度的预测价值.结果 单支病变组、双支病变组和多支病变组患儿发热持续时间、C反应蛋白(CRP)、血小板(PLT)计数、红细胞沉降率(ESR)、血清Cav-1、sLR11水平依次升高(P＜0.05).多因素分析结果显示治疗前发热持续时间(OR=1.772,95％CI:1.054～2.982,P=0.031)、血清Cav-1(OR=1.139,95％CI:1.080～1.201,P＜0.01)及sLR11(OR=1.251,95％CI:1.105～1.417,P＜0.01)均为影响KD患儿CAL严重程度的危险因素.ROC分析显示,血清Cav-1、sLR11两者联合预测KD患儿CAL严重程度的4UC为0.910(95％CI:0.854～0.951,P＜0.01).结论 血清Cav-1、sLR11两者联合对KD患儿CAL严重程度的预测效能较高.

Abstract

Objective To analyze the relationship among serum caveolin-1(Cav-1),soluble low density lipoprotein receptor 11(sLR11)and severity of coronary artery lesions(CAL)in child patients with Kawasaki disease(KD).Methods The clinical materials of child patients with KD complicated by CAL(n=153)were retrospectively analyzed in Department of Pediatrics in People's Hospital of Jiyuan City from Feb.2021 to Oct.2022.All patients were divided,according to CAL severity,into 1-vessel lesion group(n=54),2-vessel lesion group(n=68)and multi-vessel lesion group(n=31).The clinical materials and levels of serum Cav-1 and sLR11 were compared among 3 groups.The relative factors affecting CAL severity were analyzed by using multi-factor Logistic regression analysis in KD patients.The predictive value of Cav-1 and sLR11 to CAL severity were analyzed by using ROC curve in KD patients.Results The duration of fever,C-reactive protein(CRP),platelet(PLT)count,erythrocyte sedimentation rate(ESR),and levels of serum Cav-1 and sLR11 increased in turn in 1-vessel lesion group,2-vessel lesion group and multi-vessel lesion group(P＜0.05).The results of multi-factor Logistic regression analysis showed that duration of fever before treatment(OR=1.772,95％CI:1.054～2.982,P=0.031),Cav-1(OR=1.139,95％CI:1.080～1.201,P＜0.01)and sLR11(OR=1.251,95％CI:1.105～1.417,P＜0.01)were risk factors affecting CAL severity in KD patients.The results of ROC curve analysis showed that AUC of combination of Cav-1 and sLR11 was 0.910(95％CI:0.854～0.951,P＜0.01)in predicting CAL severity KD patients.Conclusion The combination of Cav-1 and sLR11 has a higher predictive efficacy for CAL severity in KD patients.

关键词

川崎病/冠状动脉病变/小窝蛋白-1/可溶性低密度脂蛋白受体11

Key words

Kawasaki disease/Coronary artery lesions/Caveolin-1/Soluble low density lipoprotein receptor 11

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基金项目

河南省医学科技攻关计划科学项目(LHGJ20210647)

出版年

2024
中国循证心血管医学杂志
中国人民解放军北京军区总医院

中国循证心血管医学杂志

CSTPCD
影响因子：1.272
ISSN：1674-4055
参考文献量6
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