Objective To discuss the expressions and significance of serum miR-93 and miR-135a in patients with acute myocardial infarction(AMI)complicated by pulmonary infection.Methods The patients with AMI complicated by pulmonary infection were chosen into disease group,and healthy controls were chosen into control group(each n=107)from Central Hospital of Xiaogan City from Apr.2018 to Apr.2021.The clinical materials,including age,hypertension and diabetes,were collected from the patients and they were followed up for 2 y.The patients were also divided,according to follow-up results,into survival group and death group,and clinical materials were compared between 2 groups.The expressions of miR-93 and miR-135a were detected by using qRT-PCR.The correlated between miR-93 level and miR-135a level were analyzed by using Pearson method.The factors affecting prognosis were analyzed by using Logistic regression analysis in AMI patients complicated by pulmonary infection.Results The expression of miR-93 was higher(P＜0.05)and expression of miR-135a was lower(P＜0.05)in disease group than those in control group.There was a negative correlated between miR-93 expression and miR-135a expression(r=-0.532,P＜0.001)in AMI patients complicated by pulmonary infection.The expression of miR-93 increased significantly(P＜0.05)and expression of miR-135a decreased significantly(P＜0.05)in survival group compared with death group.The expressions of miR-93 and miR-135a were independent influence factors in AMI patients complicated by pulmonary infection(P＜0.05).In predicting prognosis in AMI patients complicated by pulmonary infection,AUC of miR-93 was 0.835,AUC of miR-135a was 0.887,and AUC of miR-93 combined with miR-135a was 0.955.Conclusion The increased miR-93 expression and decreased miR-135a expression may be effective indexes for predicting prognosis in AMI patients complicated by pulmonary infection.
维普
万方数据