Objective Atrial fibrillation is a common arrhythmia in clinical practice,with a high prevalence rate and easy to lead to stroke.Anticoagulation therapy is the core strategy to prevent atrial fibrillation related stroke.Methods A retrospective case analysis was used to collect patients with nonvalvular atrial fibrillation who were admitted to the Cardiovascular Department of Jiangyin People's Hospital from January 2022 to December 2022.The patient's gender,age,type of atrial fibrillation,comorbidities,stroke risk score (CHA2DS2-VASc score),bleeding risk score (HAS-BLED score),related auxiliary examination and treatment plan were recorded.Results A total of 304 patients with nonvalvular atrial fibrillation were included in this study,with an average age of (70.67±11.18) years and a sex ratio of 1.14.Among the concomitant diseases and cardiovascular risk factors,189 cases (62.17%) were complicated with hypertension,156 cases (51.32%) with coronary heart disease,and 123 cases (40.46%) with heart failure.The prevalence of coronary heart disease and heart failure in patients with permanent atrial fibrillation was much higher than that in patients with paroxysmal atrial fibrillation(P<0.001).There was no significant difference in the rate of anticoagulant treatment among patients with different types of atrial fibrillation(P=0.287).The mean age of patients without anticoagulant treatment was older than that of patients with anticoagulant treatment(P<0.05).Conclusion The majority of patients with nonvalvular atrial fibrillation in our hospital are elderly.Hypertension,heart failure and coronary heart disease are the main concomitant diseases of atrial fibrillation.Most patients chose new oral anticoagulant therapy,and the overall anticoagulant ratio was relatively high,but the anticoagulant therapy was still further improved for atrial fibrillation patients with old age and bleeding history.