中国循证心血管医学杂志2024，Vol.16Issue(12) ：1506-1511.DOI:10.3969/j.issn.1674-4055.2024.12.21

老年糖尿病患者动脉粥样硬化性心血管病与葡萄糖目标范围内时间的相关性

Correlation between arteriosclerotic cardiovascular disease and time in range in elderly patients with diabetes

戴苏婕 高萌 米蕊 郝敬波 杨荣礼
中国循证心血管医学杂志2024，Vol.16Issue(12) ：1506-1511.DOI:10.3969/j.issn.1674-4055.2024.12.21
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  • 维普
  • 万方数据

老年糖尿病患者动脉粥样硬化性心血管病与葡萄糖目标范围内时间的相关性

Correlation between arteriosclerotic cardiovascular disease and time in range in elderly patients with diabetes

戴苏婕 1高萌 1米蕊 1郝敬波 1杨荣礼1
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作者信息

  • 1. 221004 徐州,徐州医科大学附属医院老年科
  • 折叠

摘要

目的 探究老年糖尿病患者动脉粥样硬化性心血管病(ASCVD)与葡萄糖目标范围内时间(TIR)的相关性.方法 选取2020年11月至2023年10月期间于徐州医科大学附属医院收治的2型糖尿病(T2DM)患者158例为研究对象,根据患者是否合并ASCVD分为ASCVD组(n=72)和非ASCVD组(n=86).收集所有患者的临床资料,比较两组临床特征及血糖指标,构建广义线性混合模型判断血糖指标与T2DM患者ASCVD之间的关系.根据TIR水平从低到高等分为四分位数组(Q1,Q4),进行TIR水平与T2DM患者ASCVD风险相关性的亚组分析.结果 158例T2DM患者中45.57％的患者发生ASCVD,ASCVD组患者年龄、糖尿病病程、高血压占比及空腹血糖(FPG)、总胆固醇(TC)、同型半胱氨酸(Hcy)水平明显高于非ASCVD组患者(P<0.05).广义线性混合模型结果显示,TIR是T2DM患者ASCVD发病的保护因素,葡萄糖高于目标范围内时间(TAR)、平均葡萄糖(MG)、血糖标准差(SDBG)、最大血糖波动幅度(LAGE)是T2DM患者ASCVD发病的危险因素(P<0.05).TIR水平与T2DM患者ASCVD风险相关性的亚组分析结果显示,年龄≥68的T2DM患者与年龄<68的T2DM患者相比,前者TIR水平与ASCVD更为明显相关(P交互=0.025).结论 ASCVD组患者TIR水平显著低于非ASCVD组,调整混杂因素后,TIR水平与T2DM患者ASCVD风险患病仍显著相关.

Abstract

Objective To investigate the correlation between arteriosclerotic cardiovascular disease (ASCVD) and time in range (TIR) in elderly patients with diabetes.Methods The patients with type 2 diabetes mellitus (T2DM,n=158) were chosen from Affiliated Hospital of Xuzhou Medical University from Nov.2020 to Oct.2023,and divided,according to whether they had ASCVD or not,into ASCVD group (n=72) and non-ASCVD group (n=86).Clinical materials were collected from all patients,and clinical features and blood glucose indexes were compared between 2 groups.A generalized linear mixed model was established to determine the relationship between blood glucose indexes and ASCVD in T2DM patients.The patients were further divided,according to TIR level,into quartile subgroups Q1,Q2,Q3 and Q4 in an ascending order.The correlation between TIR and ASCVD in T2DM patients was analyzed in subgroups.Results Among 158 patients with T2DM,45.57％ of patients suffered from ASCVD.In ASCVD group,age,diabetes course,hypertension proportion and levels of fasting blood glucose (FPG),total cholesterol (TC) and homocysteine (Hcy) were significantly higher than those in non-ASCVD group (P＜0.05).The results of generalized linear mixed model analysis showed that TIR was a protective factor for ASCVD occurrence in T2DM patients.The indexes of time above range (TAR),mean glucose (MG),standard deviation of blood glucose (SDBG) and largest amplitude of glycemic excursion (LAGE) were risk factors for ASCVD occurrence in T2DM patients.The results of subgroup analysis on correlation between TIR level and ASCVD showed that TIR level was more significantly correlated to ASCVD (Pinteraction=0.025) in patients aged≥68 compared with patients aged＜68.Conclusion The level of TIR is significantly lower in ASCVD group than that in non-ASCVD group.After adjusting confounders,TIR level is still significantly correlated to ASCVD risk in T2DM patients.

关键词

糖尿病/老年/动脉粥样硬化性心血管病/葡萄糖目标范围内时间/相关性

Key words

Diabetes/Agedness/Arteriosclerotic cardiovascular disease/Time in range/Correlation

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出版年

2024
中国循证心血管医学杂志
中国人民解放军北京军区总医院

中国循证心血管医学杂志

CSTPCD
影响因子：1.272
ISSN：1674-4055
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