中国循证心血管医学杂志2024，Vol.16Issue(12) ：1512-1515.DOI:10.3969/j.issn.1674-4055.2024.12.22

单硝酸异山梨酯对不同Apelin-13水平的老年急性心肌梗死患者心肌损伤标志物的影响

Influence of isosorbide mononitrate on biomarkers of myocardial injury in elderly patients with acute myocardial infarction with different levels Apelin-13

蒋茜 常虹 裴雪琴 梁平 胡广梅
中国循证心血管医学杂志2024，Vol.16Issue(12) ：1512-1515.DOI:10.3969/j.issn.1674-4055.2024.12.22
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  • 万方数据

单硝酸异山梨酯对不同Apelin-13水平的老年急性心肌梗死患者心肌损伤标志物的影响

Influence of isosorbide mononitrate on biomarkers of myocardial injury in elderly patients with acute myocardial infarction with different levels Apelin-13

蒋茜 1常虹 1裴雪琴 1梁平 1胡广梅1
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作者信息

  • 1. 830000 乌鲁木齐,新疆医科大学第一附属医院心血管中心高血压科
  • 折叠

摘要

目的 分析单硝酸异山梨酯对不同孤独G蛋白偶联受体配体-13(Apelin-13)水平的老年急性心肌梗死(AMI)患者心肌损伤标志物的影响.方法 选择2021年1月至2024年1月于新疆医科大学第一附属医院就诊AMI的老年患者146例为研究对象,以Apelin-13水平15.00 ng/ml为临界值,将Apelin-13>15.00 ng/ml作为高表达组,Apelin-13≤15.00 ng/ml作为低表达组,每组各73例.所有患者均予以单硝酸异山梨酯治疗,检测两组的心功能、心肌损伤标志物、血管内皮功能、血流动力学等指标,并评估治疗效果.结果 治疗后,与高表达组比较,低表达组左心室舒张末期内径(LVEDD)、心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)、N末端脑钠肽前体(NT-proBNP)、血管内皮生长因子(VEGF)、血管性血友病因子(vWF)、血浆内皮素-1(ET-1)、全血比黏度低切(BVL)、全血比黏度高切(BVH)、红细胞聚集指数(EAI)、纤维蛋白原(Fib)水平均降低(P<0.05);左室最大充盈速率(LVPFR)、左室射血分数(LVEF)水平均升高(P<0.05);低表达组治疗总有效率高于高表达组(P<0.05).结论 Apelin-13≤15.00 ng/ml的AMI老年患者应用单硝酸异山梨酯治疗后,心功能、心肌损伤标志物、血管内皮功能、血流动力学情况均予以改善,疗效满意.

Abstract

Objective To analyze the influence of isosorbide mononitrate on biomarkers of myocardial injury in elderly patients with acute myocardial infarction (AMI) with different levels of Apelin-13.Methods AMI patients (n=146) were chosen from the First Affiliated Hospital of Xinjiang Medical University from Jan.2021 to Jan.2024.Taken 15.00 ng/ml of Apelin-13 as cut-off value,the patients with Apelin-13＞15.00 ng/ml were included into high-expression group and those with Apelin-13≤15.00 ng/ml,into low-expression group (each n=73).All patients were treated with isosorbide mononitrate.The indexes of heart function,myocardial injury biomarkers,vascular endothelial function and hemodynamics were detected,and curative effect was reviewed in 2 groups.Results After treatment,the levels of left ventricular end-diastolic diameter (LVEDD),cardiac troponin I (cTnI),creatine kinase-MB isoenzyme (CK-MB),N-terminal pro-brain natriuretic peptide (NT-proBNP),vascular endothelial growth factor (VEGF),von Willebrand factor (vWF),plasma endothelin-1 (ET-1),whole blood viscosity at low share rate (BVL),whole blood viscosity at high share rate (BVH),red blood cell aggregation index (RBCAI) and fibrinogen (FIB) all decreased,and left ventricular peak filling rate (LVPFR) and left ventricular ejection fraction (LVEF) increased in low-expression group compared with high-expression group (P＜0.05).The total effective rate was higher in low-expression group than that high-expression group (P＜0.05).Conclusion After treated with isosorbide mononitrate,the conditions of heart function,biomarkers of myocardial injury,vascular endothelial function and hemodynamics are improved and curative effect is satisfactory in elderly AMI patients with Apelin-13≤15.00 ng/ml.

关键词

单硝酸异山梨酯/孤独G蛋白偶联受体配体-13/急性心肌梗死/心肌损伤标志物

Key words

Isosorbide mononitrate/Apelin-13/Acute myocardial infarction/Biomarkers of myocardial injury

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出版年

2024
中国循证心血管医学杂志
中国人民解放军北京军区总医院

中国循证心血管医学杂志

CSTPCD
影响因子：1.272
ISSN：1674-4055
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