Correlation among albumin decrease,N-terminal pro-brain natriuretic peptide increase and long-term poor prognosis in patients with chronic heart failure
Correlation among albumin decrease,N-terminal pro-brain natriuretic peptide increase and long-term poor prognosis in patients with chronic heart failure
Objective To analyze the correlation among albumin (ALB) decrease,increase of N-terminal pro-brain natriuretic peptide (NT-proBNP) and long-term poor prognosis in patients with chronic heart failure (CHF).Methods CHF patients (n=176) were chosen from Mar.2020 to Mar.2022,and divided,according to ALB median,into high-ALB group (n=96) and low-ALB group (n=80).The clinical materials were compared between 2 groups.The correlation between ALB and NT-proBNP was analyzed by using Spearman correlation analysis.The cumulative incidence rate and incidence density of all-cause rehospitalization rate and all-cause mortality were calculated within 2 y.The influence of ALB on all-cause rehospitalization rate and all-cause mortality within 2 y was analyzed by using Cox regression analysis.Results ALB median was 37.16 g/L.The levels of body mass index (BMI) and ALB was higher,and NT-proBNP level was lower in high-ALB group than those in low-ALB group.ALB was negatively correlated to NT-proBNP-log10 conversion (r=-0.217,P＜0 .001).The cumulative incidence rate and incidence density of all-cause rehospitalization rate and all-cause mortality were higher in low-ALB group than those in high-ALB group.The decreased ALB was a correlative factor to increases of all-cause rehospitalization rate and all-cause mortality in CHF patients,and was not affected by gender,heart function,NT-proBNP and β-receptor blocker.Conclusion The decreased ALB is correlated to NT-proBNP increase and long-term poor prognosis in CHF patients.Clinicians need to pay sufficient attention to nutritional status in CHF patients.
维普
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