Objective This study applied Mendelian randomization to explore the potential causal relationship between inflammatory factors and diabetic nephropathy.Methods Summary-level data from genome-wide association studies of inflammatory factors and diabetic nephropathy were used,and inverse variance weighted analysis was used as the primary analytical method,complemented by results from weighted median,MR-Egger regression,simple model,and median model approaches.Sensitivity analysis was used to test the reliability of the MR analysis results.Results In the inverse variance weighted method,stem cell factor(OR=1.28,95％CI 1.04 to 1.58,P=0.020)and interferon-y(OR=1.36,95％CI 1.10 to 1.70,P=0.005)were positively correlated with diabetic nephropathy,and diabetic nephropathy was positively correlated with interferon-inducible protein 10(OR=0.90,95％CI 0.83 to 0.98,P=0.012)were negatively correlated with diabetic nephropathy.Sensitivity analysis showed that MR analysis was reliable.Conclusion Stem cell factors and interferon-y are associated with an increased risk of developing diabetic nephropathy,and diabetic nephropathy decreases the expression of interferon-inducible protein 10 in vivo.Our results demonstrate a potential causal relationship between inflammatory factors and the development of diabetic nephropathy.This finding is of clinical significance for the pre-diagnosis and treatment of diabetic nephropathy.
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