身体基本指数与重症肌无力的因果关联:一项两样本孟德尔随机化研究
Causal association between basic body mass index and myasthenia gravis:a two-sample Mendelian randomization study
殷珂宇 1双思 2傅道森 2董文浩 2夏鹏 2张国坤 2沈蓉 2王德贵 2王青3
作者信息
- 1. 兰州大学护理学院(兰州 730000);兰州大学基础医学院人体解剖学教研室(兰州 730000)
- 2. 兰州大学基础医学院人体解剖学教研室(兰州 730000)
- 3. 兰州大学护理学院(兰州 730000)
- 折叠
摘要
目的 采用两样本孟德尔随机化分析探究4项身体基本指数(基础代谢率、体脂率、BMI及臀围)与重症肌无力(myasthenia gravis,MG)之间的因果关联.方法 在大型公开可检索的数据库中获取全基因关联分析汇总数据,选取4项身体基本指数作为暴露因素,MG作为结局因素,筛选出与暴露因素表型强相关的单核苷酸多态性作为工具变量,进行两样本孟德尔随机化分析,以评估暴露与疾病之间的潜在因果关系.结果 逆方差加权法分析结果显示,基础代谢率[OR=1.39,95％CI(1.00,1.93),P=0.047]、体脂率[OR=1.61,95％CI(1.06,2.44),P=0.024]、臀围[OR=1.67,95％CI(1.29,2.17),P＜0.001]升高均会增加 MG 发病风险,但 BMI 与 MG 没有显著的因果关联.结论 基础代谢率、体脂率及臀围对MG存在致病效应,BMI与MG没有显著的因果关系.
Abstract
Objective A two-sample Mendelian randomization analysis was used to explore the causal associations between four basic body indices(basal metabolic rate,body fat percentage,BMI and hip circumference)and myasthenia gravis(MG).Methods Pooled gene-wide association study(GWAS)data were obtained from large publicly searchable databases,and four basic body indices were selected as the exposure factors and myasthenia gravis as the outcome factors,and single nucleotide polymorphisms(SNPs),which were strongly correlated with the phenotype of the exposure factors,were screened as the instrumental variables,and two-sample Mendelian randomization analyses were performed in order to assess the potential causal relationship between the exposure and the disease.Results Inverse variance weighting(IVW)analysis showed that increased basal metabolic rate(OR=1.39,95％CI 1.00 to 1.93,P=0.047),body fat percentage(OR=1.61,95％CI 1.06 to 2.44,P=0.024),and hip circumference(OR=1.67,95％CI 1.29 to 2.17,P＜0.001)increased the risk of MG.But there was no significant causal relationship between BMI and MG.Conclusion Basal metabolic rate,body fat percentage and hip circumference have a positive causal relationship with MG,while BMI does not have a significant causal relationship with MG.
关键词
身体基本指数/重症肌无力/孟德尔随机化/因果关联Key words
Body basic index/Myasthenia gravis/Mendelian randomization/Causal association引用本文复制引用
基金项目
甘肃省科技计划项目(20JR10RA637)
中央高校基本科研业务费项目(lzujbky-2022-30)
国家卫生健康委胃肠道肿瘤诊疗重点实验室开放基金项目(NLDTG2020006)
兰州市青年科技人才创新项目(2023-QN-79)
&&(2023CXZX-143)
出版年
2024
NETL
NSTL
万方数据