Association between multiple sclerosis and inflammatory bowel diseases:a Mendelian randomization study
Objective To conduct a two-sample Mendelian randomization(MR)study to assess the bidirectional causal relationship between multiple sclerosis and inflammatory bowel disease.Methods We performed two-sample bidirectional MR analysis using publicly available genome-wide association study(GWAS)data.The primary analysis method used was the inverse variance weighted(IVW)method,with MR-Egger weighted median as a supplementary analysis.Sensitivity analyses were conducted.Results IVW,weighted median,and weighted mode all supported a causal relationship between multiple sclerosis and an increased risk of ulcerative colitis(OR=1.07,95％CI 1.01 to 1.13,P=0.018),while no association was found between multiple sclerosis and Crohn's disease.Sensitivity analyses suggested that the study results were not affected by pleiotropy.Conclusion Genetic predisposition to multiple sclerosis is associated with an elevated risk of developing ulcerative colitis but not Crohn's disease.
Mendelian randomizationMultiple sclerosisInflammatory bowel diseaseCausal association
NETL
NSTL
万方数据
