多发性硬化与炎症性肠病的因果关联:一项两样本双向孟德尔随机化研究
Association between multiple sclerosis and inflammatory bowel diseases:a Mendelian randomization study
徐婷 1袁名扬 1侯德仁1
作者信息
- 1. 中南大学湘雅三医院(长沙 410013)
- 折叠
摘要
目的 采用两样本孟德尔随机化(Mendelian randomization,MR)研究方法评估多发性硬化与炎症性肠病之间双向因果关系.方法 使用公开可访问的全基因组关联研究数据进行双样本双向MR分析.主要分析采用逆方差加权法(inverse variance weighted,IVW),补充分析采用MR-Egger加权中位数法,并进行了敏感性分析.结果 IVW、加权中位数和加权模式支持多发性硬化与溃疡性结肠炎风险增加存在因果关系[OR=1.07,95％CI(1.01,1.13),P=0.018],而多发性硬化与克罗恩病之间没有发现关联,敏感性分析提示研究结果不具有多效性.结论 遗传预测多发性硬化与患溃疡性结肠炎的风险升高有关,但与克罗恩病无关.
Abstract
Objective To conduct a two-sample Mendelian randomization(MR)study to assess the bidirectional causal relationship between multiple sclerosis and inflammatory bowel disease.Methods We performed two-sample bidirectional MR analysis using publicly available genome-wide association study(GWAS)data.The primary analysis method used was the inverse variance weighted(IVW)method,with MR-Egger weighted median as a supplementary analysis.Sensitivity analyses were conducted.Results IVW,weighted median,and weighted mode all supported a causal relationship between multiple sclerosis and an increased risk of ulcerative colitis(OR=1.07,95％CI 1.01 to 1.13,P=0.018),while no association was found between multiple sclerosis and Crohn's disease.Sensitivity analyses suggested that the study results were not affected by pleiotropy.Conclusion Genetic predisposition to multiple sclerosis is associated with an elevated risk of developing ulcerative colitis but not Crohn's disease.
关键词
孟德尔随机化/多发性硬化/炎症性肠病/因果关联Key words
Mendelian randomization/Multiple sclerosis/Inflammatory bowel disease/Causal association引用本文复制引用
基金项目
中央高校基本科研业务费专项中南大学项目(CX20220375)
湖南省自然科学基金(2024JJ5541)
出版年
2024
NETL
NSTL
万方数据