Association between gastroesophageal reflux disease and obstructive sleep apnea:a Mendelian randomization study
Objective To investigate the causal relationship between gastroesophageal reflux disease(GERD)and obstructive sleep apnea(OSA)with its typical symptoms(snoring and daytime sleepiness)by using Mendelian randomization(MR).Methods The inverse-variance weighted method was used as the main analysis method to assess the causal effect.Sensitivity and pleiotropy analyses were carried out using leave-one-out and MR-Egger analysis,and then heterogeneity tests were conducted.Results In the MR analysis,genetically predicted GERD was associated with a greater risk of OSA(IVW:OR=1.528,95％CI 1.374 to 1.699,P=5.315E-15).Additional MR results were consistent with the I VW results,and no pleiotropy or heterogeneity was found.We also discovered a significant causal relationship between GRED and snoring(IVW:OR=0.959,95％CI 0.949 to 0.969,P=1.507E-15),and daytime sleepiness(IVW:OR=1.024,95％CI 1.021 to 1.036,P=4.580E-5),with no evidence of pleiotropy.Conclusion The MR study supports a causal effect between GERD and OSA with its typical symptoms(daytime sleepiness and snoring).
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