首页|cGAS-STING信号通路调节剂在免疫治疗中的研究进展

cGAS-STING信号通路调节剂在免疫治疗中的研究进展

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环鸟嘌呤-腺嘌呤核苷酸合成酶(cGAS)-干扰素基因刺激蛋白(STING)信号通路感知细胞质中的异常双链DNA后,诱导Ⅰ型干扰素(IFN-Ⅰ)和促炎细胞因子表达,从而激活宿主的免疫应答,增强机体抗肿瘤免疫反应和抗病原体感染.但是,cGAS-STING信号通路的持续激活会驱动自身免疫性疾病、衰老相关炎症和神经退行性病变等疾病.本文阐述了cGAS-STING信号通路参与调控多种免疫相关性疾病发生发展的机制,重点回顾了STING激动剂、cGAS抑制剂以及STING抑制剂的研发进展,为cGAS-STING调节剂的研发提供更多理论参考.
Research progress of cGAS-STING signaling pathway modulators in immunotherapy
Upon monitoring cytoplasmic aberrant double-stranded DNA,cGAS-STING signaling pathway induces the expression of type I interferons and pro-inflammatory cytokines,which activates the host immune response and enhances anti-tumor immune response and resistance to pathogen infection.However,sustained activation of the cGAS-STING signaling pathway drives diseases such as autoimmune diseases,aging-associated inflammation,and neurodegenerative pathologies.Herein,we describe the mechanism by which cGAS-STING signaling pathway participates in regulating the development of various immune-related diseases,with a particular review of the research and development progress of STING agonists,cGAS inhibitors,and STING inhibitors,aiming to provide some theoretical reference for the future development of cGAS-STING modulators.

cGAS-STING signaling pathwaySTING agonistcGAS inhibitorSTING inhibitorimmunotherapy

娄方宁、郑明月、陈凯先、张素林

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中国药科大学药学院, 南京 211198

中国科学院上海药物研究所, 原创新药研究全国重点实验室,药物发现与设计中心, 上海 201203

cGAS-STING信号通路 STING激动剂 cGAS抑制剂 STING抑制剂 免疫治疗

国家自然科学基金国家自然科学基金国家重点研发计划项目中国科学院青年创新促进会资助项目上海市自然科学基金

T2225002822738552022YFC3400504202329622ZR1474300

2024

10.11665/j.issn.1000-5048.2023112402

中国药科大学学报
中国药科大学

中国药科大学学报

CSTPCD北大核心
影响因子：0.655
ISSN：1000-5048
年,卷(期)：2024.55(1)
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