靶向蛋白S-棕榈酰化修饰在T细胞免疫疗法中的研究进展
Research progress on targeted protein S-palmitoylation modification in T cell immunotherapy
孙丽婷 1张为国 2童玥3
作者信息
- 1. 中国药科大学生命科学与技术学院, 南京 211198;中国医学科学院北京协和医学院苏州系统医学研究所, 苏州 215123
- 2. 中国医学科学院北京协和医学院苏州系统医学研究所, 苏州 215123
- 3. 中国药科大学生命科学与技术学院, 南京 211198
- 折叠
摘要
S-棕榈酰化是细胞内一种可逆且动态的蛋白质翻译后修饰,参与调控下游靶基因转录、表达以及信号转导,进而影响细胞生命活动.研究发现数千种人类蛋白质经历S-棕榈酰化修饰,表明S-棕榈酰化与疾病发生发展以及治疗之间存在很大程度的关联性.T细胞是机体抗肿瘤免疫的主力军,多种T细胞免疫相关蛋白受S-棕榈酰化调节.本文围绕S-棕榈酰化对T细胞信号转导的影响及在T细胞免疫疗法中的应用展开论述,为T细胞免疫治疗新靶点及多肽抑制剂的开发提供新思路.
Abstract
S-palmitoylation,a reversible and dynamic post-translational modification in cells,is involved in regulating the transcription and expression of downstream target genes as well as signal transduction,thereby affecting cell life activities.Studies have shown that thousands of human proteins undergo S-palmitoylation modification,suggesting that S-palmitoylation is closely related to the progression and treatment of diseases.T cells play central roles in anti-tumor immune responses.A variety of T cell immune-related proteins are regulated by S-palmitoylation.In the present study,we focus on the impact of S-palmitoylation on T cell signal transduction and its application in T cell immunotherapy,aiming to provide new ideas for the development of new targets and peptide inhibitors for T cell immunotherapy.
关键词
S-棕榈酰化/DHHC/T细胞/免疫疗法/肽抑制剂Key words
S-palmitoylation/DHHC/T cells/immunotherapy/peptide inhibitors引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据