Research progress of Bruton's tyrosine kinase(BTK)inhibitors in the treatment of inflammatory and immune-mediated diseases
Bruton's tyrosine kinase(BTK),a cytoplasmic tyrosine kinase,plays a central role in the activation of B cells and granulocytes,operating downstream of B cell and Fcγ receptors,and is considered an attractive target for treating autoimmune diseases.Preclinical investigations have demonstrated that inhibition of BTK activity holds promise as a potential therapeutic strategy for inflammatory immune responses such as autoimmune diseases and allergies.This review provides an overview of the mechanisms by which BTK contributes to immune-related diseases and summarizes current research on the development of BTK inhibitors for treating these conditions,aiming to offer novel insights into non-oncology applications for BTK inhibitors.
BTKinflammatory immunityautoimmune diseasesallergyclinical research
国家科技期刊平台
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