首页|氮氧自由基衍生物及其生物活性的研究进展

氮氧自由基衍生物及其生物活性的研究进展

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氮氧自由基是一类稳定的有机自由基,因其结构中具有N-O·及未成对电子等而表现出诸多特性,可作为自旋标记物用于探索生物反应机制,具有磁学性质可用于多功能磁性分子材料的开发,具有阻聚和催化作用可用于有机反应中的阻聚剂和催化剂等.更重要的是其具有抗氧化、抗肿瘤等多种生物活性,在新药的研发方面备受人们关注,如将氮氧自由基自旋标记于抗癌药物鬼臼毒素可起到增效减毒,易于机体吸收等作用,得到了新的抗癌药物 4-[4″-(2″,2″,6″,6″-四甲基哌啶氮氧自由基)氨基]-4′-去甲基表鬼臼毒(GP-7).通过引入药效团对氮氧自由基进行结构修饰,或将其自旋标记于中药活性成分等,从而得到高效低毒的新化合物,是寻求新药物的有效途径.对新型氮氧自由基衍生物及其生物活性等方面的研究进行归纳总结,旨在为开发利用氮氧自由基,寻找治疗疾病新药物提供理论依据.
Research progress of nitroxide radical derivatives and their biological activities
Nitroxide radicals are a kind of stable organic free radicals.Due to the presence of N-O·and unpaired electrons in its structure,it has many characteristics,and thus can be used as a spin marker to explore the mechanism of biological reactions;with its magnetic properties,it can be used for the development of multifunctional magnetic molecular materials and used as a polymerization inhibitor and catalyst in organic reactions.More importantly,it has a variety of biological activities such as anti-oxidation and anti-tumor,and so has attracted much attention in the research and development of new drugs.For example,the spin labeling of nitroxide radicals on anticancer drug podophyllotoxin can enhance the efficacy and reduce the toxicity,and can be easily to be absorbed by the body,thus obtaining a new anti-cancer drug 4-[4″-(2″,2″,6″,6″-tetramethyl-1″-piperidinyloxy nitroxide radical)amino]-4′-demethyl epipodophyllotoxin(GP-7).It is an effective way to seek new drugs by introducing pharmacophore to modify nitroxide radicals or it can be spin-labeled on active natural products to obtain new compounds with high efficiency and low toxicity.The research progress of derivatives and its biological activitives of nitroxide radicals are summarized,aiming to provide theoretical basis for the developing and utilizing of nitroxide radicals and searching for new drugs.

nitroxide radicalsstructural modificationderivativebioactivityresearch progress

张启立、田雪、王洁、赵磊、夏鹏飞、续艳丽、徐富梅、贾寅强

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甘肃中医药大学,兰州 730000

陇药产业创新研究院,兰州 730000

西北中藏药省部共建协同创新中心,兰州 730000

甘肃省道地药材质量标准化技术研究与推广工程实验室,兰州 730000

甘肃省高校中藏药化学与质量研究省级重点实验室,兰州 730000

兰州市食品药品检验检测研究院,兰州 730000

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氮氧自由基 结构修饰 衍生物 生物活性 研究进展

国家自然科学基金项目国家自然科学基金项目甘肃省科技计划项目甘肃省教育厅"双一流"科研重点项目甘肃省道地药材质量标准化技术研究与推广工程实验室开放基金项目甘肃省高校教师创新基金项目

821604578166057721JR7RA564GSSYLXM-05ddyc-2022-032023B-115

2024

10.11665/j.issn.1000-5048.2023041902

中国药科大学学报
中国药科大学

中国药科大学学报

CSTPCD北大核心
影响因子：0.655
ISSN：1000-5048
年,卷(期)：2024.55(5)
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