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药用辅料在中药制剂中的应用研究进展

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药用辅料作为制剂不可或缺的关键部分,扮演着充当药物载体、改善药物释放、保障药品稳定性及提高患者顺应性的重要角色.中医药在我国有着悠久的历史,随着科学技术的现代化发展,药学、化学与材料学深度交叉融合,为中药制剂的创新研发提供了更为广阔的空间,而与此同时制药行业对优质辅料的需求也日益凸显.本文旨在综述中药制剂辅料的研究进展,具体涵盖预混与共处理辅料、物理及化学改性辅料、"药辅合一"辅料包括矫味剂、填充剂、促透剂及在递送系统中的应用等,通过对现有研究的梳理与分析,探讨各类辅料在中药制剂中的具体应用现状,以期为中药制剂辅料的选择提供思路,并促进中药制剂辅料领域的创新活力,呼吁开发适合中药制剂的个性化辅料.
Advances in research on the application of pharmaceutical excipients in traditional Chinese medicine preparations
Pharmaceutical excipients,as an indispensable part of drug preparation,play crucial roles as drug carriers,improving drug release,ensuring drug stability,and enhancing patient compliance.Traditional Chinese Medicine(TCM)boasts a rich developmental history.With the modernization of technology,the deep integration of pharmacy,chemistry,and materials science has provided broader opportunities for innovative research in TCM.Simultaneously,the demand for high-quality excipients has become increasingly critical.This paper aims to review current research and applications of excipients in TCM preparations,including pre-mixed and co-processed excipients,modified excipients,and the unification of drugs and excipients,such as flavoring agents,fillers,penetration enhancers,and delivery systems.A meticulous synthesis and analysis of existing research aims to provide a reference for selecting excipients in TCM preparations,stimulate innovation in excipient development for TCM,and advocate for the development of personalized excipients.

pharmaceutical excipientstraditional Chinese medicine preparationspre-mixed and co-processed excipientsmodified excipientsunification of drugs and excipients

缪妍、胡丽琴、张珂、钱帅、高缘、张建军、魏元锋

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中国药科大学中药学院,南京 211198

中国药科大学药学院,南京 211198

药用辅料 中药制剂 预混与共处理辅料 改性辅料 药辅合一

2024

中国药科大学学报
中国药科大学

中国药科大学学报

CSTPCD北大核心
影响因子:0.655
ISSN:1000-5048
年,卷(期):2024.55(6)