中国药科大学学报2024,Vol.55Issue(6) :734-741.DOI:10.11665/j.issn.1000-5048.2024082902

药用辅料在中药制剂中的应用研究进展

Advances in research on the application of pharmaceutical excipients in traditional Chinese medicine preparations

缪妍 胡丽琴 张珂 钱帅 高缘 张建军 魏元锋
中国药科大学学报2024,Vol.55Issue(6) :734-741.DOI:10.11665/j.issn.1000-5048.2024082902

药用辅料在中药制剂中的应用研究进展

Advances in research on the application of pharmaceutical excipients in traditional Chinese medicine preparations

缪妍 1胡丽琴 2张珂 2钱帅 1高缘 1张建军 2魏元锋1
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作者信息

  • 1. 中国药科大学中药学院,南京 211198
  • 2. 中国药科大学药学院,南京 211198
  • 折叠

摘要

药用辅料作为制剂不可或缺的关键部分,扮演着充当药物载体、改善药物释放、保障药品稳定性及提高患者顺应性的重要角色.中医药在我国有着悠久的历史,随着科学技术的现代化发展,药学、化学与材料学深度交叉融合,为中药制剂的创新研发提供了更为广阔的空间,而与此同时制药行业对优质辅料的需求也日益凸显.本文旨在综述中药制剂辅料的研究进展,具体涵盖预混与共处理辅料、物理及化学改性辅料、"药辅合一"辅料包括矫味剂、填充剂、促透剂及在递送系统中的应用等,通过对现有研究的梳理与分析,探讨各类辅料在中药制剂中的具体应用现状,以期为中药制剂辅料的选择提供思路,并促进中药制剂辅料领域的创新活力,呼吁开发适合中药制剂的个性化辅料.

Abstract

Pharmaceutical excipients,as an indispensable part of drug preparation,play crucial roles as drug carriers,improving drug release,ensuring drug stability,and enhancing patient compliance.Traditional Chinese Medicine(TCM)boasts a rich developmental history.With the modernization of technology,the deep integration of pharmacy,chemistry,and materials science has provided broader opportunities for innovative research in TCM.Simultaneously,the demand for high-quality excipients has become increasingly critical.This paper aims to review current research and applications of excipients in TCM preparations,including pre-mixed and co-processed excipients,modified excipients,and the unification of drugs and excipients,such as flavoring agents,fillers,penetration enhancers,and delivery systems.A meticulous synthesis and analysis of existing research aims to provide a reference for selecting excipients in TCM preparations,stimulate innovation in excipient development for TCM,and advocate for the development of personalized excipients.

关键词

药用辅料/中药制剂/预混与共处理辅料/改性辅料/药辅合一

Key words

pharmaceutical excipients/traditional Chinese medicine preparations/pre-mixed and co-processed excipients/modified excipients/unification of drugs and excipients

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出版年

2024
中国药科大学学报
中国药科大学

中国药科大学学报

CSTPCD北大核心
影响因子:0.655
ISSN:1000-5048
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