β淀粉样蛋白与年龄相关性白内障
β-amyloid and age-related cataracts
郑天玉 1徐婕 1卢奕1
作者信息
- 1. 复旦大学附属眼耳鼻喉科医院眼科卫生部近视眼重点实验室 上海200031
- 折叠
摘要
白内障是世界首位致盲性眼病,而年龄相关性白内障(ARC)是其中最主要的类型.ARC的发病机制以及非手术干预已经成为了研究热点.近来,研究者在多种证据支持下提出ARC与阿尔兹海默病(AD)可能存在类似的发病机制;因此,导致AD发生的关键物质β-淀粉样蛋白(Aβ)与ARC的相关性受到了特别关注.本文主要就Aβ与ARC的相关性研究进展作一综述.
Abstract
Cataract is the most common cause of blindness worldwide,while age-related cataract (ARC) is the main subtype of cataract.The pathogenesis and non-surgical therapies of ARC have become the research hotspots.Recently,with multiple supporting evidences,researchers have demonstrated that ARC formation might share a common mechanism with Alzheimer disease (AD) pathogenesis.Thus,the correlation between ARC and β-amyloid (Aβ) which plays a critical role in the pathogenesis of AD causes special concern.This article mainly reviewed the advances in the research of correlation between Aβ and ARC.
关键词
白内障,年龄相关性/β淀粉样蛋白/淀粉样蛋白前体/β分泌酶/氧化应激Key words
Cataract, age-related/β-amyloid/Amyloid precursor protein/β-secretase/Oxidative stress引用本文复制引用
基金项目
国家自然科学基金面上项目(81270989)
国家自然科学基金青年项目(81300747)
高等学校博士学科点专项科研基金(20130071120096)
上海青年医师培养资助计划(第三批)()
出版年
2017
NETL
NSTL
维普
万方数据