To explore the value of the eosinophil cationic protein-myeloperoxidase(ECP-MPO)test strip in the treatment of allergic rhinitis.Methods Forty-eight patients with allergic rhinitis were randomly divided into sea saline group,biroph group,budesonide nasal spray group and biroph combined with budesonide group.The results of the ECP-MPO test strip and the concentration of ECP and MPO in nasal secretion were obtained before and after treatment as well as the clinical symptom scores.The differences of indexes within and between groups were compared.The correlations between each index/index difference/index change rate and symptom score/score difference/score change rate were analyzed.Results Except sea saline group,the concentrations of ECP all decreased after treatment in the other groups(P＜0.05).The concentration of MPO in either the biroph group or the combination group after treatment were all lower than those before treatment.The positive rates of ECP-MPO test card in different groups after treatment was lower than that before treatment.The results of test strip before and after treatment were both positively correlated with the concentrations of ECP in nasal secretion,and the results of test strip after treatment were positively correlated with the scores of symptoms.There was a positive correlation between the results of test strip and the concentration of ECP in nasal secretions after treatment in either biroph group(r=0.805,P＜0.05)or combination group(r=0.826,P＜0.05).A positive correlation between the results of ECP-MPO test strip and symptom scores of nasal secretion in either budesonide group or combination group after treatment was confirmed as well.However,no significant correlation existed between other indexe/index difference/index change rate and symptom score/score difference/score change rate.Conclusions The examination of ECP-MPO test strip in nasal secretion can be utilized to evaluate the efficacy of drug symptomatic treatment preliminarily.Combination of ECP concentration and clinical symptom score is expected to become a new avenue to evaluate the efficacy of drug treatment in allergic rhinitis.
维普
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